Cancer Leading Proteases

📒Cancer Leading Proteases ✍ Satya Prakash Gupta

Cancer Leading Proteases Book PDF
✏Book Title : Cancer Leading Proteases
✏Author : Satya Prakash Gupta
✏Publisher : Academic Press
✏Release Date : 2020-02-03
✏Pages : 526
✏ISBN : 9780128181683
✏Available Language : English, Spanish, And French

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✏Cancer Leading Proteases Book Summary : Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancer Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers Covers a wide range of cancers and provides detailed discussions on protease examples

📒The Cancer Degradome ✍ Dylan Edwards

The Cancer Degradome Book PDF
✏Book Title : The Cancer Degradome
✏Author : Dylan Edwards
✏Publisher : Springer Science & Business Media
✏Release Date : 2008-09-16
✏Pages : 926
✏ISBN : 9780387690575
✏Available Language : English, Spanish, And French

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✏The Cancer Degradome Book Summary : This book covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; and many other relevant subjects, including new approaches to targeting proteolysis for therapy.

Proteases And Their Inhibitors In Cancer Metastasis Book PDF
✏Book Title : Proteases and Their Inhibitors in Cancer Metastasis
✏Author : J-M. Foidart
✏Publisher : Springer Science & Business Media
✏Release Date : 2002
✏Pages : 256
✏ISBN : 9781402009235
✏Available Language : English, Spanish, And French

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✏Proteases and Their Inhibitors in Cancer Metastasis Book Summary : In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also taken into account. This volume offers an update on this challenging aspect of cancer treatment, its interest bias, and possible clinical implication.

Matrix Proteases In Health And Disease Book PDF
✏Book Title : Matrix Proteases in Health and Disease
✏Author : Niels Behrendt
✏Publisher : John Wiley & Sons
✏Release Date : 2012-09-10
✏Pages : 416
✏ISBN : 9783527649341
✏Available Language : English, Spanish, And French

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✏Matrix Proteases in Health and Disease Book Summary : Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these disease states, as well as therapeutic strategies based on protease inhibition. With its trans-disciplinary scope, this reference bridges the gap between fundamental research and biomedical and pharmaceutical application, making this required reading for basic and applied scientists in the molecular life sciences.

Proteases In Gastrointestinal Tissues Book PDF
✏Book Title : Proteases in Gastrointestinal Tissues
✏Author : Uwe Lendeckel
✏Publisher : Springer Science & Business Media
✏Release Date : 2006-05-09
✏Pages : 344
✏ISBN : 9781402044830
✏Available Language : English, Spanish, And French

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✏Proteases in Gastrointestinal Tissues Book Summary : This book is unique for its comprehensive presentation of protease function in the stomach, colon, pancreas and liver under both physiological conditions and major diseases manifesting in these four organs. The individual chapters have been written by leaders in the field who outline in great detail the role of proteases in the pathogenesis, diagnosis and treatment of disease. Animal models and experimental data are discussed in the context of patient-derived data.

Proteases As Targets For Therapy Book PDF
✏Book Title : Proteases as Targets for Therapy
✏Author : M. Abdel-Meguid
✏Publisher : Springer Science & Business Media
✏Release Date : 2000
✏Pages : 410
✏ISBN : 3540661182
✏Available Language : English, Spanish, And French

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✏Proteases as Targets for Therapy Book Summary : This volume is the first to combine latest information on viral, microbial and cellular proteolytic enzymes as potential targets for human therapeutics. Proteases control a large array of physiological reactions, and are involved in a variety of pathological processes for which effective medications are currently needed and/or being sought after. Although protease inhibitors have been investigated for many years, few have been employed therapeutically. Recent break- through by HIV protease inhibitors as therapeutic drugs has re-encouraged the search for inhibitors of other proteolytic enzymes. Klaus von der Helm, who described the first viral protease has brought leading experts together to discuss not only the success and problems of clinical use and continuing prospects, but to review further potential drug targets. This volume provides detailed information and evaluations of key viral, bacterial, fungal, and cellular proteases as potential future drug candidates.

📒Proteases In The Brain ✍ Uwe Lendeckel

Proteases In The Brain Book PDF
✏Book Title : Proteases in the Brain
✏Author : Uwe Lendeckel
✏Publisher : Springer Science & Business Media
✏Release Date : 2006-01-20
✏Pages : 384
✏ISBN : 9780387231013
✏Available Language : English, Spanish, And French

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✏Proteases in the Brain Book Summary : In all organs of the body, proteases have critical roles to play both in normal development and functioning and in disease states. The brain is no exception to this, with proteases having emerging roles in synaptic plasticity, memory, neurodegenerative disorders such as Alzheimer’s, Parkinson’s and prion diseases, ischemia and traumatic brain injury, inflammatory and infectious diseases, and tumor progression. Proteases in the Brain brings together a wide range of topics under this central theme and highlights the large number of proteases involved in these normal and disease processes. Proteases in the Brain reviews the role and regulation of proteases in, Alzheimer’s disease, brain ischemia and traumatic brain injury, human glioma, inflammatory and infectious diseases of the central nervous system, metabolism of the prion protein, modulating synaptic activity, multiple sclerosis, neuronal plasticity and memory consolidation, Parkinson’s disease, processing, conversion and inactivation of neuropeptides. Proteases in the Brain is a timely and useful source of information both for those well-versed in the role of proteases in the brain, and for those who are beginning to realize the important role of this family of enzymes in brain function and dysfunction.

Transforming Growth Factor Beta In Cancer Therapy Volume I Book PDF
✏Book Title : Transforming Growth Factor Beta in Cancer Therapy Volume I
✏Author : Sonia B. Jakowlew
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-01-01
✏Pages : 735
✏ISBN : 9781597452922
✏Available Language : English, Spanish, And French

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✏Transforming Growth Factor Beta in Cancer Therapy Volume I Book Summary : Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.

Role Of Proteases In Cellular Dysfunction Book PDF
✏Book Title : Role of Proteases in Cellular Dysfunction
✏Author : Naranjan S. Dhalla
✏Publisher : Springer Science & Business Media
✏Release Date : 2013-11-22
✏Pages : 462
✏ISBN : 9781461490999
✏Available Language : English, Spanish, And French

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✏Role of Proteases in Cellular Dysfunction Book Summary : It is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can result, as seen in Alzheimer’s disease, cancer metastasis and tumor progression, inflammation and atherosclerosis. Thus it is evident that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues. Aimed at graduate students and researchers with an interest in cellular proteolytic events, Role of Proteases in Cellular Dysfunctions is the second book on Proteases in this series. The book consists of three parts in specified topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The first section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases and matrix metalloproteases (MMPs). The second section covers the deadly disease cancer and its relation to ubiquitin-proteasome system, MMPs and serine proteases. The last section is about the role of proteases such as calpains, MMPs and serine protease as well as urokinase type plasminogen activator receptor (uPAR) in causing cardiovascular defects.

Proteases Structure And Function Book PDF
✏Book Title : Proteases Structure and Function
✏Author : Klaudia Brix
✏Publisher : Springer Science & Business Media
✏Release Date : 2014-01-21
✏Pages : 564
✏ISBN : 9783709108857
✏Available Language : English, Spanish, And French

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✏Proteases Structure and Function Book Summary : Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic agents is extremely promising. Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins. This book reflects the efforts of many in this exciting field of research where team and network formations are essential to move ahead.

📒Cancer And Nutrition ✍ Kedar N. Prasad

Cancer And Nutrition Book PDF
✏Book Title : Cancer and Nutrition
✏Author : Kedar N. Prasad
✏Publisher : IOS Press
✏Release Date : 1998
✏Pages : 251
✏ISBN : 9051993773
✏Available Language : English, Spanish, And French

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✏Cancer and Nutrition Book Summary : This book discusses the role of nutrients and vitamins in cancer prevention and treatment. Basic and clinical scientists from different regions of the world have contributed to this volume. The incidence of cancer is on the rise internationally and many of these cancers appear to be attributable to diet, lifestyle, and environmentally related factors. In recent years, many cancer causing substances and cancer protective agents which are associated with these factors have been identified and extensively tested in experimental models. This work also focuses on newer conceptual ideas that have emerged regarding the functions of nutrients on cellular and molecular levels.

Cancer Immunology Innovative Approaches To Therapy Book PDF
✏Book Title : Cancer Immunology Innovative Approaches to Therapy
✏Author : Ronald B. Herberman
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-12-06
✏Pages : 230
✏ISBN : 9781461326298
✏Available Language : English, Spanish, And French

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✏Cancer Immunology Innovative Approaches to Therapy Book Summary : This volume is the second in the 'Cancer Treatment and Research' series focussing on basic and clinical tumor immunology. It has a rather different focus or emphasis from that of the first volume, published two years ago. That work (Basic and Clinical Tumor Immunology, R.B. Herberman, ed., Martinus Nijhoff Publishers, 1983) devoted considerable attention to up dated summaries in various areas of classical tumor immunology: specific antitumor immunity, the immunologic competence of cancer patietns, char acterization of human tumor-associated antigens, the ability to propagate specifically immune T cells in culture in the presence of interleukin 2, and the use of such cells for adoptive immunotherapy of established tumors. of evidence concerning the immune However, it also reviewed the status surveillance hypothesis and pointed out the need to consider non-T cell mediated mechanisms of host resistance. In particular, one chapter sum marized information on the role of macrophages in host resistance against tumors. The present volume continues to emphasize one of the major themes of the first volume, innovative approaches to the therapy of cancer. It involves contributions from leading investigators on several primary types of therapeutic interventions related to monoclonal antibodies, the col laboration of monoclonal antibodies with macro phages to mediate antibody dependent cellular cytotoxicity, lymphokines, tumor vaccines, and natural killer cells. It also has an up-to-date summary of the immunologic aspects of the exciting and promising work being performed on human T cell leukemia virus in the laboratory of Dr. Robert Gallo.

Leading Topics In Cancer Research Book PDF
✏Book Title : Leading Topics in Cancer Research
✏Author : Lee P. Jeffries
✏Publisher : Nova Publishers
✏Release Date : 2007
✏Pages : 331
✏ISBN : 1600213324
✏Available Language : English, Spanish, And French

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✏Leading Topics in Cancer Research Book Summary : Cancer is a group of different diseases (more than 100) characterised by uncontrolled growth and spread of abnormal cells. Cancer can arise in many sites and behave differently depending on its organ of origin. Significant progress has been made in recent years in the battle against cancer and in understanding its underlying biological mechanisms. This research progress has resulted in many experimental treatments and cures. This book brings together important research from around the world in this frontal field.

📒Head And Neck Cancer ✍ John Frederick Ensley

Head And Neck Cancer Book PDF
✏Book Title : Head and Neck Cancer
✏Author : John Frederick Ensley
✏Publisher : Academic Press
✏Release Date : 2003-01-06
✏Pages : 602
✏ISBN : UOM:39015051921008
✏Available Language : English, Spanish, And French

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✏Head and Neck Cancer Book Summary : Introduction. -- Basic Molecular Mechanisms. -- Prevention and Detection. -- Current Approaches. -- Novel Approaches.

📒Hemostasis And Thrombosis ✍ Thomas G. DeLoughery

Hemostasis And Thrombosis Book PDF
✏Book Title : Hemostasis and Thrombosis
✏Author : Thomas G. DeLoughery
✏Publisher : Springer
✏Release Date : 2014-11-12
✏Pages : 172
✏ISBN : 9783319093123
✏Available Language : English, Spanish, And French

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✏Hemostasis and Thrombosis Book Summary : Since the second edition of Hemostasis and Thrombosis published over a decade ago, advances on assessing, treating and preventing common and rare hemostatic problems have emerged. This latest edition features these new developments while providing practical information on diagnosing and managing these troublesome conditions often found in clinical practice. Concise and convenient, healthcare professionals will find this text to be an invaluable resource.

Apoptotic Pathways As Targets For Novel Therapies In Cancer And Other Diseases Book PDF
✏Book Title : Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases
✏Author : Marek Los
✏Publisher : Springer Science & Business Media
✏Release Date : 2006-06-20
✏Pages : 395
✏ISBN : 9780387236957
✏Available Language : English, Spanish, And French

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✏Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases Book Summary : As our understanding of apoptotic pathway expands, we are coming to realize the great potential of utilizing this pathway to treat diseases such as cancer. The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients. Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways. The reader by the end of the book should have greater insight into the understanding and utilization of apoptotic pathways to fight diseases such as cancer.

Biochemical Targets Of Plant Bioactive Compounds Book PDF
✏Book Title : Biochemical Targets of Plant Bioactive Compounds
✏Author : Gideon Polya
✏Publisher : CRC Press
✏Release Date : 2003-05-15
✏Pages : 860
✏ISBN : 0203013719
✏Available Language : English, Spanish, And French

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✏Biochemical Targets of Plant Bioactive Compounds Book Summary : When introduced to the human body, bioactive metabolites produced by plants for self defense bind to particular biochemical targets, most notably to proteins involved in signaling by hormones and neurotransmitters. This, essentially, is the basis for the effects of herbal medicine. While herbal medicine preparations may act by complex synergistic interactions, molecular explanations of herbal medicine efficacy and side effects ultimately require definition of the biochemical targets of individual plant bioactive constituents. Biochemical Targets of Plant Bioactive Compounds is a comprehensive and user-friendly reference guide to biochemical targets of plant defensive compounds. With 500 pages of tables, it presents a mine of succinctly summarized information relating to bioactive compound structures, plant sources, biochemical targets and physiological effects that can be readily accessed via chemical compound, plant genus, plant common name and subject indexes. With introductory chapters providing reviews of the structural diversity of plant defensive compounds and biochemistry, this book is an invaluable reference for biomedical professionals in the fields of alternative/complementary medicine, natural product chemistry, toxicology, pharmacology, and botany.

Cancer Research Program Annual Report To The California State Legislature  Book PDF
✏Book Title : Cancer Research Program Annual Report to the California State Legislature
✏Author : Cancer Research Program (Calif.)
✏Publisher :
✏Release Date : 2000
✏Pages :
✏ISBN : UCR:31210017773605
✏Available Language : English, Spanish, And French

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✏Cancer Research Program Annual Report to the California State Legislature Book Summary :

📒Optical Imaging Of Cancer ✍ Eben Rosenthal

Optical Imaging Of Cancer Book PDF
✏Book Title : Optical Imaging of Cancer
✏Author : Eben Rosenthal
✏Publisher : Springer Science & Business Media
✏Release Date : 2009-10-03
✏Pages : 272
✏ISBN : 0387938745
✏Available Language : English, Spanish, And French

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✏Optical Imaging of Cancer Book Summary : To describe principles of optical imaging including chemistry and physics of fluorescence, limitations/advantages of optical imaging compared to metabolic and anatomic imaging. Describe hardware adapted for small animal imaging and for clinical applications: endoscopes and operative microscopes. Outline FDA approved and newer optical imaging probes. Include discussion of chemistry and linkage to other proteins. Review current techniques to image cancer and the development of techniques to specifically image cancer cells. Review use of exploiting differences in tissue autofluorescence to diagnose and treat cancer. Include agents such as 5-aminoleculinic acid. Review mechanisms that require proteolytic processing within the tumor to become active fluorophores. Review use of cancer selective proteins to localize probes to cancer cells: include toxins, antibodies, and minibodies. Introduction of plasmids, viruses or other genetic material may be used to express fluorescent agents in vivo. This chapter will review multiple vectors and delivery mechanisms of optical imaging cassettes.Preclinical investigations into the use of optical contrast agents for the detection of primary tumors in conventional and orthotopic models will be discussed. Preclinical investigations into the use of optical contrast agents for the detection of metastatic tumors in mouse models will be discussed. Use of targeted and non-specific optical contrast agents have been used for the detection of sentinel lymph node detection. These applications and how they differ from other applications will be discussed. Because of the unique difficulty of identifying tumor from normal tissue in brain tissue, a separate chapter would be needed. More clinical data is available for this cancer type than any other. Discussion of potential clinical applications for optical imaging and an assessment of the potential market.

Cancer Immunotherapy At The Crossroads Book PDF
✏Book Title : Cancer Immunotherapy at the Crossroads
✏Author : James H. Finke
✏Publisher : Springer Science & Business Media
✏Release Date : 2003-11-24
✏Pages : 386
✏ISBN : 9781592597437
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy at the Crossroads Book Summary : Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction. The authors review the mechanisms of immune dysfunction and evasion mechanisms in histologically diverse human tumors, focusing on tumor-induced molecular defects in T cells and antigen-presenting cells (dendritic cells and tumors), that may serve as biomarkers for patient prognosis. They discuss the means by which these immune functions may be protected or restored in order to more effectively support the process of tumor rejection in situ. Cutting-edge techniques are outlined with the capacity to monitor the strength and quality of patients' immune responses using immunocytometry, MHC-peptide tetramers combined with apoptosis assay, ELISPOT assay, and detection of MHC-TAA peptide complexes on tumor cells.

Cancer Research Book PDF
✏Book Title : Cancer Research
✏Author :
✏Publisher :
✏Release Date : 2007
✏Pages :
✏ISBN : NWU:35558005616467
✏Available Language : English, Spanish, And French

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✏Cancer Research Book Summary :

📒Cancer ✍ Maurice Israël

Cancer Book PDF
✏Book Title : Cancer
✏Author : Maurice Israël
✏Publisher : John Libbey Eurotext
✏Release Date : 2005
✏Pages : 117
✏ISBN : 2742005978
✏Available Language : English, Spanish, And French

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✏Cancer Book Summary : In this book the authors suggest that a 'dysmethylation syndrome' may affect the vital regulation of cell growth, metabolism and mitosis, and may then lead to cancer. These dysmethylations (which may be hyper- or hypo-methylations) affect not only the expression of the genes involved in growth and mitosis, but also the activity of enzymes such as phosphatase PP2A, which is assembled after methylation. This phosphatase limits the effects of the trophic kinases activated by growth factors or oncogenes. In the neurones, the syndrome associated with a deficit in the methylation of phosphatase and other substrates favours the accumulation of hyperphosphorylated proteins, as in Alzheimer's disease. This would mean that cancer and Alzheimer's disease, as well as Biermer's anaemia, are linked to cellular methylations.

Pancreatic Cancer Cystic Neoplasms And Endocrine Tumors Book PDF
✏Book Title : Pancreatic Cancer Cystic Neoplasms and Endocrine Tumors
✏Author : Hans G. Beger
✏Publisher : John Wiley & Sons
✏Release Date : 2015-02-26
✏Pages : 456
✏ISBN : 9781118307830
✏Available Language : English, Spanish, And French

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✏Pancreatic Cancer Cystic Neoplasms and Endocrine Tumors Book Summary : Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors:Diagnosis and Management is a modern, expertly crafted andclinically focused guide to the diagnosis, management andbest-practice care of patients suffering from pancreatic cancer,cystic neoplasms and endocrine tumours. Packed with outstanding figures and with reference to theleading society guidelines, its main focus is on the manyendoscopic and radiologic diagnostic techniques, medical andsurgical management of both full-blown cancer and other tumors, andthe risks of each form of treatment. Also covered in detailare issues of tumor recurrence and long-term outcome oftreatment. Brought to you by highly skilled national and internationalleaders in the specialty and an experienced editor team, this is aninvaluable guide to practicing gastroenterologists and surgeons inthe hospital and clinical environment, as well as oncologists andendocrinologists managing patients with pancreatic tumorouslesions.

Protein Kinase C In Cancer Signaling And Therapy Book PDF
✏Book Title : Protein Kinase C in Cancer Signaling and Therapy
✏Author : Marcelo G. Kazanietz
✏Publisher : Springer Science & Business Media
✏Release Date : 2010-06-10
✏Pages : 494
✏ISBN : 9781607615439
✏Available Language : English, Spanish, And French

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✏Protein Kinase C in Cancer Signaling and Therapy Book Summary : Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents. Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. Moreover, it is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable. This book will have 4 sections. There will be 23 chapters. Each section will have a brief introduction by an expert in the field (~ 1-2 pages).

Pathophysiology For The Health Professions E Book Book PDF
✏Book Title : Pathophysiology for the Health Professions E Book
✏Author : Barbara E. Gould
✏Publisher : Elsevier Health Sciences
✏Release Date : 2014-04-11
✏Pages : 736
✏ISBN : 9780323292405
✏Available Language : English, Spanish, And French

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✏Pathophysiology for the Health Professions E Book Book Summary : A concise, easy-to-understand introduction to the fundamentals, Pathophysiology for the Health Professions, 4th Edition helps you learn to identify disease processes and disorders. Authors Barbara Gould and Ruthanna Dyer continue the tradition of a text known for its readability and vivid, full-color illustrations, updated with the latest research and clinical advances. Unique Challenge, Think About, and Emergency Treatment features help in applying the material to real-life situations. No matter which area in the healthcare field you may enter, this book provides essential preparation for conditions encountered in clinical practice. Concise and readable approach includes the information students need without overwhelming them, even if they have a limited scientific background. Unique Challenge feature asks "What can go wrong with this structure or system?" as a way to help students facilitate progress by using previously learned knowledge. Unique Think About boxes help with self-evaluation, test preparation, and review. Unique Emergency Treatment boxes list basic emergency measures; these can be modified to fit specific professions, established protocols, or practice settings. Research boxes discuss new developments, problem areas of pathophysiology, and complications associated with research. Warning Signs boxes summarize conditions that may develop in patients. Diagnostic tests and treatments are included for each of the major disorders. Case studies in each chapter provide a basis for discussion or can be used as an assignment. Study questions offer a self-assessment on the material in each chapter. Ready References in the appendix provide a quick lookup for anatomic terms, conversion tables, abbreviations and acronyms, diagnostic studies and tests, and more. A companion Evolve website includes web links, learning activities, content updates, and more. New content on the causes and trends related to disease, new drugs, technology, and treatment. Coverage of obesity and its complications, including an in-depth discussion of metabolic syndrome. Multiple disorder syndromes in the aged client. DNA, genetics and the Human Genome Project with current research on protein pathways in health (proteomics) and the implications for drug treatment and disease causation. Coverage of autism. Updated content on the H1N1 virus and communicable diseases; HIV, cancer causation, and immunology; and substance abuse to reflect common practices in the use of illicit (street) drugs as well as abuse of prescription medications. Case studies revised to emphasize chronic diseases, prevention, and acute care, and to apply to a wider range of health professions. Appendices reorganized for improved reference and lookup.

📒Apoptosis And Cancer Therapy ✍ Klaus-Michael Debatin

Apoptosis And Cancer Therapy Book PDF
✏Book Title : Apoptosis and Cancer Therapy
✏Author : Klaus-Michael Debatin
✏Publisher : Wiley-Blackwell
✏Release Date : 2006-03-17
✏Pages : 1159
✏ISBN : CHI:75184735
✏Available Language : English, Spanish, And French

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✏Apoptosis and Cancer Therapy Book Summary : Since most cancer therapies primarily act by inducing apoptosis in tumor cells, insights into the molecular mechanisms regulating apoptosis are crucial to developing novel, more effective treatment strategies. Here, a highly distinguished team of authors from top institutes around the world leads readers from the principles of programmed cell death to the role of apoptosis in cancer development and emerging treatment strategies. Divided into two distinct parts, the first focuses on apoptosis signaling, covering in depth such topics as mitochondria, effector systems, the Bcl-2 family, IAPs, survival pathways, tumor suppressor genes, modulators, lysosomes and phagocytosis. The second section goes on to analyze apoptosis in cancer and cancer therapy, with a detailed look at model systems, molecular diagnosis, cellular stress, DNA damage and repair, molecular targets and therapeutic aspects. With its strong focus on recent developments in cancer therapy, this book is aimed at oncologists, molecular and cell biologists, biochemists, and those working in the pharmaceutical and biotechnological industries.

Biological Chemistry Book PDF
✏Book Title : Biological Chemistry
✏Author :
✏Publisher :
✏Release Date : 2004
✏Pages :
✏ISBN : UCLA:L0090240052
✏Available Language : English, Spanish, And French

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✏Biological Chemistry Book Summary :

Standard Poor S Stock Reports Book PDF
✏Book Title : Standard Poor s Stock Reports
✏Author :
✏Publisher :
✏Release Date : 2001-06
✏Pages :
✏ISBN : CORNELL:31924088600535
✏Available Language : English, Spanish, And French

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✏Standard Poor s Stock Reports Book Summary :

Anticancer Research Book PDF
✏Book Title : Anticancer Research
✏Author :
✏Publisher :
✏Release Date : 2000
✏Pages :
✏ISBN : UCLA:L0081626616
✏Available Language : English, Spanish, And French

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✏Anticancer Research Book Summary :

📒Cns Cancer ✍ Erwin G. Van Meir

Cns Cancer Book PDF
✏Book Title : CNS Cancer
✏Author : Erwin G. Van Meir
✏Publisher : Springer Science & Business Media
✏Release Date : 2009-08-15
✏Pages : 1284
✏ISBN : 1603275533
✏Available Language : English, Spanish, And French

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✏CNS Cancer Book Summary : Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy, and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders. It is small wonder that such cancers have come under the intense scrutiny of each of the subspecialties of clinical care and investigation as well as attracting some of the best basic research scientists. Their joint efforts are gradually peeling away the mysteries surrounding the genesis and progression of these tumors and inroads are being steadily made into understanding why they resist therapies. This makes it an especially opportune time to assemble some of the best investigators in the field to review the ‘‘state of the art’’ in the various arenas that comprise the assault on CNS tumors. The breadth of this effort by the clinical and basic neuro-oncology community is quite simply amazing. To a large extent, it evolves from the knowledge of the human genome and its regulation that has been hard won over the past two decades.