Cancer Immunotherapy

📒Cancer Immunotherapy ✍ George C. Prendergast

Cancer Immunotherapy Book PDF
✏Book Title : Cancer Immunotherapy
✏Author : George C. Prendergast
✏Publisher : Academic Press
✏Release Date : 2013-06-04
✏Pages : 684
✏ISBN : 9780123946331
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy Book Summary : There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease. Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication Drs. Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research Summarizes the latest insights into how immune escape defines an essential trait of cancer Includes numerous illustrations, including how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy and how reversing immune suppression by the tumor can cause tumor regression

Vaccines For Cancer Immunotherapy Book PDF
✏Book Title : Vaccines for Cancer Immunotherapy
✏Author : Nima Rezaei
✏Publisher : Academic Press
✏Release Date : 2018-10-17
✏Pages : 198
✏ISBN : 9780128140406
✏Available Language : English, Spanish, And French

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✏Vaccines for Cancer Immunotherapy Book Summary : Therapeutic cancer vaccines represent a type of active cancer immunotherapy. Clinicians, scientists, and researchers working on cancer treatment require evidence-based and up-to-date resources relating to therapeutic cancer vaccines. Vaccines for Cancer Immunotherapy provides a reference for cancer treatment for clinicians and presents a well-organized resource for determining high-potential research areas. The book considers that this promising modality can be made more feasible as a treatment for cancer. Chapters cover cancer immunology, general approaches to cancer immunotherapy, vaccines, tumor antigens, the strategy of allogeneic and autologous cancer vaccines, personalized vaccines, whole-tumor antigen vaccines, protein and peptide vaccines, dendritic cell vaccines, genetic vaccines, candidate cancers for vaccination, obstacles to developing therapeutic cancer vaccines, combination therapy, future perspectives and concluding remarks on therapeutic cancer vaccines. Introduces the feasible immunotherapeutic vaccines for patients with different types of cancer Presents the status of past and current vaccines for cancer treatment Considers advantages and disadvantages of different therapeutic cancer vaccines Looks at the combination of vaccines and other modalities, including immunotherapeutic and conventional methods Analyzes obstacles to development of therapeutic cancer vaccines Gives a view on future perspectives in the application of therapeutic cancer vaccines

📒Cancer Immunotherapy ✍ Alberto Mantovani

Cancer Immunotherapy Book PDF
✏Book Title : Cancer Immunotherapy
✏Author : Alberto Mantovani
✏Publisher : Elsevier Inc. Chapters
✏Release Date : 2013-06-04
✏Pages : 684
✏ISBN : 9780128059234
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy Book Summary : Tumor development and progression are strongly linked to inflammation and macrophage infiltration is a major component of the inflammatory reactions associated with neoplasia. Plasticity is a hallmark of mononuclear phagocytes, which undergo polarized diverse forms of activation. Metabolic adaptation is a key component of macrophage plasticity and polarization, instrumental to their function in homeostasis, immunity and inflammation. Tumor-associated macrophages (TAM) and related immature myeloid suppressor cells generally have properties of an M2-like population. TAM produce growth factors, have immunoregulatory and immunosuppressive activity, stimulate angiogenesis and provide tissue remodeling, invasion and metastasis. Thus, TAM are a key component of cancer-promoting inflammatory reactions.

Tumor Immunology And Immunotherapy Book PDF
✏Book Title : Tumor Immunology and Immunotherapy
✏Author : Robert C. Rees
✏Publisher : Oxford University Press, USA
✏Release Date : 2014-05-20
✏Pages : 442
✏ISBN : 9780199676866
✏Available Language : English, Spanish, And French

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✏Tumor Immunology and Immunotherapy Book Summary : Patients are beginning to benefit from antibody based, cellular and vaccine approaches that are effective against genetically diverse and therapy-resistance cancers. BCG immunotherapy is now being used as a first line treatment for human bladder cancer and the introduction of prophylactic vaccination against Hepatitis B and HPV cancers is starting to show positive results. Following recent FDA approval for a vaccination against prostate cancer, and optimistic results in clinical trials for a vaccine targeting cancer antigens in lung cancer, cancer immunotherapy is now significantly impacting patient clinical management. Tumor Immunology and Immunotherapy provides an up-to-date and comprehensive account of cancer immunity and immunotherapy. It discusses our adaptive and innate immunity to cancer, the mechanisms underpinning our immune response, current approaches to cancer immunotherapy, and how tumour and host responses can circumvent effective anti-cancer immunity. The book examines recent results, publications and current areas of interest including 'immune editing' and the specific issues that are affecting the research and development of vaccines, providing insight into how these problems may be overcome, as viewed by world leaders in the field. Tumor Immunology and Immunotherapy will appeal to clinicians working in oncology and cancer immunotherapy, and research scientists including PhD and masters students, post-doctoral researchers and senior investigators.

📒Cancer Immunotherapy ✍ James Allison

Cancer Immunotherapy Book PDF
✏Book Title : Cancer Immunotherapy
✏Author : James Allison
✏Publisher : Elsevier
✏Release Date : 2006-05-19
✏Pages : 400
✏ISBN : 9780080463377
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy Book Summary : For some time immunotherapy has been heralded as a breakthrough approach for cancer treatment. Although the potential of this strategy remains solid, the approach needs considerable refinement. Whilst some programmes are looking to increase the understanding of molecular and cellular mechanisms underlying the stimulation of antitumor immunity, others are trying to find the most appropriate clinical setting that will reveal the role of the immune system in combating cancer. Among the most important discoveries have been tumor-specific antigens. This thematic volume highlights some key issues and discusses where they may move forward. It has been put together by two leading cancer immunotherapists from two eminent institutions that focus on cancer research.

Cancer Immunology And Immunotherapy Book PDF
✏Book Title : Cancer Immunology and Immunotherapy
✏Author : Glenn Dranoff
✏Publisher : Springer Science & Business Media
✏Release Date : 2011-04-11
✏Pages : 306
✏ISBN : 3642141366
✏Available Language : English, Spanish, And French

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✏Cancer Immunology and Immunotherapy Book Summary : The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.

📒Cancer Immunotherapy ✍ Jeffrey Schlom

Cancer Immunotherapy Book PDF
✏Book Title : Cancer Immunotherapy
✏Author : Jeffrey Schlom
✏Publisher : Elsevier Inc. Chapters
✏Release Date : 2013-06-04
✏Pages : 684
✏ISBN : 9780128059166
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy Book Summary : This article reviews progress made in the design and development of recombinant poxviral-based vaccines that express transgenes for tumor-associated antigens (TAAs) and human T-cell co-stimulatory molecules (designated TRICOM). The TRICOM vaccine platform consists of priming with a recombinant vaccinia (rV-) vector and multiple boosts with a replication defective fowlpox (rF-) vector. The rV, rF-PSA-TRICOM (PROSTVAC) has demonstrated survival benefit in randomized trials. rV, rF-CEA-MUC1-TRICOM (PANVAC) has demonstrated evidence of benefit in patients with colorectal, breast and ovarian cancers. Preclinical studies with TRICOM-based vaccines have demonstrated their ability to be used in combination with anti-CTLA4 monoclonal antibody, radiation, chemotherapeutics, and small molecule targeted therapies to enhance vaccine-mediated immune responses and antitumor activity. Randomized clinical studies have been completed, are ongoing, and are planned employing several of these TRICOM vaccine combination therapies. The importance of trial design in terms of patient population and clinical trial endpoint has been demonstrated in these studies.

The Basics Of Cancer Immunotherapy Book PDF
✏Book Title : The Basics of Cancer Immunotherapy
✏Author : Haidong Dong
✏Publisher : Springer
✏Release Date : 2018-01-05
✏Pages : 160
✏ISBN : 9783319706221
✏Available Language : English, Spanish, And French

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✏The Basics of Cancer Immunotherapy Book Summary : This book provides patients and their physicians (especially “non-oncologist” health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient’s own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitating greater awareness for both patients and physicians in order to minimize complications of therapy. The patient-friendly, concise, easy-to-understand, and up-to-date knowledge presented in this book will inform patients about the benefits and risks of cancer immunotherapy, and help them and their care providers to understand how immunotherapy would control their unique disease. Researchers and academic professionals in the field of cancer immunotherapy will also find clear and useful information to help them communicate with patients or address unresolved problems. Some key features of the book are: Expertise. All editors and authors are scientists and oncologists specializing in cancer immunotherapy, and are involved in scientific discovery from the early stage of immune-checkpoint inhibitors to today’s daily patient care. Their insights, expertise and experience guarantee the high quality and authority in the science, medicine and practice of cancer immunotherapy. Patient-friendly. This book is written for cancer patients in order to meet their needs when considering immunotherapy. As an educational tool, this book will help the reader balance the risks and benefits based on both science and clinical facts, and therefore to make the best choice in receiving or withdrawing from immunotherapy. Disease Specificity. Cancer is a complicated disease involving multiple stages and pathology. Its response to immunotherapy is individualized and varies depending on cancer types. The authors’ expertise in treating different types of cancers, including melanoma, lung, kidney, bladder, and lymphoma, provides disease-specific insights in applying immunotherapy to each disease.

Cancer Immunotherapy Research And Practice Book PDF
✏Book Title : Cancer Immunotherapy Research and Practice
✏Author : Molly Finch
✏Publisher :
✏Release Date : 2020-09-15
✏Pages : 240
✏ISBN : 1632418401
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy Research and Practice Book Summary : Cancer immunotherapy is a growing field of oncology that is concerned with the artificial stimulation of the immune system for the treatment of cancer. This is achieved by enhancing the body's natural ability to fight cancer. In cancer immunotherapy, antibody proteins of the immune system detect cancer cells by binding to them. The chief difference between normal and modified immunotherapy antibodies lies in the fact that while the former binds to external pathogens, the latter binds to tumor antigens thereby identifying and marking the cancer cells for the immune system to kill or inhibit their growth. Cancer immunotherapy can be passive, hybrid or active. Hybrid therapy is a combination of active and passive therapies. In active immunotherapy, the immune system is directed to attack tumor cells by targeting tumor antigens. Passive immunotherapies improve existing anti-tumor responses by using lymphocytes, cytokines and monoclonal antibodies. Some of the approved immunotherapy antibodies are nivolumab, alemtuzumab, ofatumumab, ipilimumab and rituximab. This book elucidates new techniques and applications of cancer immunotherapy in a multidisciplinary manner. It explores all the important aspects of cancer immunotherapy research and practice in the present day scenario. It will prove to be immensely beneficial to students and researchers in this field.

📒Cancer Immunotherapy ✍ Margaret K. Callahan

Cancer Immunotherapy Book PDF
✏Book Title : Cancer Immunotherapy
✏Author : Margaret K. Callahan
✏Publisher : Elsevier Inc. Chapters
✏Release Date : 2013-06-04
✏Pages : 684
✏ISBN : 9780128059159
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy Book Summary : Ipilimumab is the first drug to show a survival benefit for patients with advanced melanoma and was approved by the US Food and Drug Administration in March of 2011. Ipilimumab enhances antitumor immunity by enhancing T-cell function by blocking the negative regulatory molecule, cytotoxic T-lymphocyte antigen 4 (CTLA-4). Unlike traditional cancer therapy, ipilimumab’s effects may be delayed and occur after initial apparent disease progression. A distinct set of side effects have been described, and ongoing efforts continue to characterize immunologic changes associated with patients who benefit from therapy. Efforts to characterize ipilimumab’s clinical activity in malignancies other than melanoma are ongoing.

📒Cancer Immunotherapy ✍ Ende Zhao

Cancer Immunotherapy Book PDF
✏Book Title : Cancer Immunotherapy
✏Author : Ende Zhao
✏Publisher : Elsevier Inc. Chapters
✏Release Date : 2013-06-04
✏Pages : 684
✏ISBN : 9780128059067
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy Book Summary : As a new member of the helper T cell subsets, Th17 cells have triggered more and more interest in exploring their development, regulation, function and therapeutic manipulation in distinct context since they were identified in 2005. This also causes a lot of confusion and debate about the generation and function of Th17 cells, especially their activity in the tumor immunopathology as our understanding grows. However, it is worth asserting that the most confusing part arises from the Th17-associated cytokines including IL-17 and IL-23 rather than the Th17 cells. IL-17 cytokine is not synonymous with Th17-cell subset, although IL-17 is the lineage-signature cytokine for Th17 cells. We will discuss the generation, cytokine profile, genetic control, plasticity and stemness of Th17 cells and address the role of Th17 cells and their associated cytokines in tumor immunity, and further explore the potential immunotherapy by targeting Th17 cells and their cytokines.

Part I Understanding Cancer Immunotherapy A Brief Review Part Ii What Is Chimeric Antigen Receptor Car T Cell Therapy An Emerging Cancer Treatment Modality  Book PDF
✏Book Title : Part I Understanding Cancer Immunotherapy A brief Review Part II What is Chimeric Antigen Receptor CAR T Cell Therapy An Emerging Cancer Treatment Modality
✏Author : Dr. Hakim Saboowala
✏Publisher : Dr.Hakim Saboowala
✏Release Date : 2020-05-12
✏Pages :
✏ISBN :
✏Available Language : English, Spanish, And French

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✏Part I Understanding Cancer Immunotherapy A brief Review Part II What is Chimeric Antigen Receptor CAR T Cell Therapy An Emerging Cancer Treatment Modality Book Summary : Part I- Understanding Cancer Immunotherapy: A brief Review. Immunotherapy, also called biologic therapy, is a type of cancer treatment that boosts the body's natural defenses to fight cancer. It uses substances made by the body or in a laboratory to improve or restore immune system function. Immunotherapy may work by: Stopping or slowing the growth of cancer cells Stopping cancer from spreading to other parts of the body Helping the immune system work better at destroying cancer cells There are several types of immunotherapy, including: Monoclonal antibodies and tumor-agnostic therapies Non-specific immunotherapies Oncolytic virus therapy T-cell therapy Cancer vaccines Part II- “What is Chimeric Antigen Receptor (CAR) T- Cell Therapy?” An Emerging Cancer Treatment Modality. Chimeric antigen receptor (CAR) T-cell therapy is an emerging cancer treatment modality in which the patients’ own immune cells are collected, genetically engineered to recognize a tumor-related target, expanded in vitro, and then reinfused to produce responses and prevent progression in a variety of malignancies (ie, adoptive cell transfer) Several types of adoptive cell transfer(ACT) are under investigation, but CAR T-cell therapy is the first to enter clinical practice. Like other technologies, CAR-T cell therapy has undergone a long development process in the past. Chimeric antigen receptor- (CAR-) T cell therapy is one of the most recent innovative immunotherapies and is rapidly evolving. At present, CAR-T cell therapy is developing rapidly, and many clinical trials have been established on a global scale, which has great commercial potential. I have endeavored to compile this E- Booklet into Two Parts i.e. Part I & Part II for better understanding of Chimeric antigen receptor (CAR) T-cell therapy, an emerging cancer treatment modality. In Part I, an effort has been made to describe Cancer Immunotherapy briefly whereas in Part II know about of CAR T-Cell Therapy-the first to enter clinical practice- has been embodied. Further it is attempted to describe toxicity of CAR-T cell therapy briefly and future development and opportunities for immunotherapy. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

📒Cancer Immunotherapy ✍ Tyler J. Curiel

Cancer Immunotherapy Book PDF
✏Book Title : Cancer Immunotherapy
✏Author : Tyler J. Curiel
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-11-07
✏Pages : 486
✏ISBN : 9781461447320
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy Book Summary : This work will provide a historical perspective on tumor immunotherapy, discuss fundamental mechanisms of failed tumor rejection, look at passive strategies to boost anti-tumor immunity, as well as have an in-depth look at active strategies to boost anti-tumor immunity.

📒Ovarian Cancer Immunotherapy ✍ Samir A. Farghaly

Ovarian Cancer Immunotherapy Book PDF
✏Book Title : Ovarian Cancer Immunotherapy
✏Author : Samir A. Farghaly
✏Publisher : Oxford University Press
✏Release Date : 2018-08-31
✏Pages : 352
✏ISBN : 9780190248215
✏Available Language : English, Spanish, And French

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✏Ovarian Cancer Immunotherapy Book Summary : Ovarian Cancer Immunotherapy provides a broad overview of several aspects of basic sciences, and clinical and therapeutic aspects of immunotherapy for ovarian cancer, as well as state-of-the-art information on molecular genetics and biology. Chapters are written by a team of expert contributors from around the world and explore topics such as antibody therapeutics for ovarian carcinoma, emerging serum biomarkers, ovarian cancer immunity, adoptive cell immunotherapy, the biology of dendritic cells, the role of growth factors, and more. Readers will also gain a better understanding of the molecular and cellular events that underlie ovarian cancer immunology. This book is an ideal resource for clinicians, basic medical scientists, graduate basic medical science students, and medical students caring for patients with ovarian cancer, including attending surgeons and physicians, and clinical fellows and residents in the disciplines of gynecologic oncology, medical oncology, and surgical oncology.

📒Cancer Immunotherapy Meets Oncology ✍ Cedrik Michael Britten

Cancer Immunotherapy Meets Oncology Book PDF
✏Book Title : Cancer Immunotherapy Meets Oncology
✏Author : Cedrik Michael Britten
✏Publisher : Springer
✏Release Date : 2014-04-23
✏Pages : 248
✏ISBN : 9783319051048
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy Meets Oncology Book Summary : This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.

📒Cancer Immunotherapy ✍ Eva Sahakian

Cancer Immunotherapy Book PDF
✏Book Title : Cancer Immunotherapy
✏Author : Eva Sahakian
✏Publisher : Elsevier Inc. Chapters
✏Release Date : 2013-06-04
✏Pages : 684
✏ISBN : 9780128059180
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy Book Summary : Histone deacetylase inhibitors (HDI) have been largely known for their ability to induce cell cycle arrest and apoptosis of tumor cells, effects that have translated into clinically significant antitumor activity against certain malignancies. In addition, there is now increasing evidence that HDIs are also endowed with immunoregulatory properties. Interestingly, while some reports have highlighted the anti-inflammatory effects of these compounds, others have shown pro-inflammatory effects triggered by HDIs in in vitro and in vivo studies. Known targets for HDIs are histone deacetylases (HDACs), enzymes that are recruited to gene promoters where they regulate transcription through histone modifications. Some HDACs, however, can also deacetylate nonhistone proteins, indicating that the role of HDACs in cell biology goes beyond their initial described effects on histones and encompasses now more complex regulatory functions. This complexity, along with the fact that most of the HDI currently in use are pan-HDI (multiple HDAC targets), might explain the divergent immunoregulatory effects of these compounds. Given this conundrum, in this chapter we have summarized the current understanding of the expression/function of specific HDACs in immune cells, knowledge that is providing important insights into their role in immunobiology and also paving the way for the development of more selective and potentially less toxic epigenetic-based approaches to effectively harness antitumor immune responses.

Progress In Cancer Immunotherapy Book PDF
✏Book Title : Progress in Cancer Immunotherapy
✏Author : Shuren Zhang
✏Publisher : Springer
✏Release Date : 2016-05-30
✏Pages : 283
✏ISBN : 9789401775557
✏Available Language : English, Spanish, And French

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✏Progress in Cancer Immunotherapy Book Summary : This book provides readers an extensive overview of recent progress in basic and clinical research on cancer immunotherapy. Thanks to rapid advances in molecular biology and immunology, it has become increasingly evident that cancer growth is influenced by host immune responses. With the success of a number of clinical trials, immunotherapy has become a promising treatment modality of cancer. This book covers five major topics, including monoclonal antibodies, biological response modifiers, cancer vaccines, adoptive cellular therapy and oncolytic viruses. It also examines the combination of different immune strategies as well as the combination of immunotherapy with other treatments to increase anti-tumor effects. Through the comprehensive discussion of the topic, the book sheds valuable new light on the treatment of tumors.

📒Cancer Immunotherapy ✍ George C. Prendergast

Cancer Immunotherapy Book PDF
✏Book Title : Cancer Immunotherapy
✏Author : George C. Prendergast
✏Publisher : Elsevier
✏Release Date : 2011-04-28
✏Pages : 428
✏ISBN : 0080521851
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy Book Summary : There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumoral immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease. * Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication * Drs Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research * Summarizes the latest insights into how immune escape defines an essential trait of cancer * Includes numerous illustrations including: how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy; and how reversing immune suppression by the tumor can cause tumor regression

Cancer Immunotherapy At The Crossroads Book PDF
✏Book Title : Cancer Immunotherapy at the Crossroads
✏Author : James H. Finke
✏Publisher : Springer Science & Business Media
✏Release Date : 2003-11-24
✏Pages : 386
✏ISBN : 9781592597437
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy at the Crossroads Book Summary : Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction. The authors review the mechanisms of immune dysfunction and evasion mechanisms in histologically diverse human tumors, focusing on tumor-induced molecular defects in T cells and antigen-presenting cells (dendritic cells and tumors), that may serve as biomarkers for patient prognosis. They discuss the means by which these immune functions may be protected or restored in order to more effectively support the process of tumor rejection in situ. Cutting-edge techniques are outlined with the capacity to monitor the strength and quality of patients' immune responses using immunocytometry, MHC-peptide tetramers combined with apoptosis assay, ELISPOT assay, and detection of MHC-TAA peptide complexes on tumor cells.

Cancer Immunotherapy Immuno Monitoring Mechanism Treatment Diagnosis And Emerging Tools Book PDF
✏Book Title : Cancer Immunotherapy Immuno monitoring Mechanism Treatment Diagnosis and Emerging Tools
✏Author : Chao Ma
✏Publisher : Frontiers E-books
✏Release Date : 2014-12-16
✏Pages :
✏ISBN : 9782889193806
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy Immuno monitoring Mechanism Treatment Diagnosis and Emerging Tools Book Summary : In the past decade, significant progresses have taken place in the field of cancer immunotherapy. Tumor-targeting immunotherapies are being developed for most human cancers, including melanoma, prostate cancer, glioblastoma, sarcoma, lung carcinoma and hepatocellular carcinoma. The FDA has approved multiple molecular immunotherapeutics, such as Ipilimumab; cellular immunotherapies (e.g. adoptive cell transfer) are being tested in phase II/III clinical trials. Immunotherapetics has evolved into a sophisticated field: Multimodal therapeutic regimens are administrated to induce focused responses, curtail side- effects and improve therapeutic efficacy. The lack of effective clinical assessment tools remains a major challenge. Because of the intricacy of antitumor response, it is essential to scrutinize individual tumor-targeting immune cells and their functions at the finest details – molecules. In this regard, flow cytometry analysis modernized hematology and allows characterization of surface molecular signature on individual cells. More recently, microchip technologies and new variations of cytometry have enormously expanded the spectrum, throughout and multiplexity of single cell analysis. Nowadays, tens of millions of readouts can be generated through the course of a cancer immunotherapy to monitor the abundance, phenotype and a myriad of effector functions of single immune cells. At the same time, big data analytics and data mining methodologies have been adapted to achieve sensible diagnostic interpretations. Such a marriage of technology and analytics opens the door for informative point-of-care assessment of therapeutic efficacy and ensures timely therapeutic decisions. The new generation of personalized clinical diagnostics will revolutionize healthcare in the years to come.

Innate Immune Regulation And Cancer Immunotherapy Book PDF
✏Book Title : Innate Immune Regulation and Cancer Immunotherapy
✏Author : Rong-Fu Wang
✏Publisher : Springer Science & Business Media
✏Release Date : 2012-02-02
✏Pages : 478
✏ISBN : 1441999140
✏Available Language : English, Spanish, And French

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✏Innate Immune Regulation and Cancer Immunotherapy Book Summary : Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.

General Principles Of Tumor Immunotherapy Book PDF
✏Book Title : General Principles of Tumor Immunotherapy
✏Author : Howard L. Kaufman
✏Publisher : Springer Science & Business Media
✏Release Date : 2007-10-22
✏Pages : 503
✏ISBN : 9781402060861
✏Available Language : English, Spanish, And French

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✏General Principles of Tumor Immunotherapy Book Summary : "General Principles of Tumor Immunotherapy: Basic and Clinical Applications of Tumor Immunology" brings together the world’s leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated through both experimental clinical trials and review of current standard of care therapeutic agents. This information will be invaluable to both students of immunology and cancer research and practicing physicians who have patients with cancer. The book provides a comprehensive overview of the field, demonstrates how advances in basic immunology can and are being applied to cancer, and describes the current status of approved immunotherapy regimens.

Vaccines Developed For Cancer Immunotherapy Book PDF
✏Book Title : Vaccines Developed for Cancer Immunotherapy
✏Author : Aizong Shen
✏Publisher :
✏Release Date : 2018
✏Pages :
✏ISBN : OCLC:1154291730
✏Available Language : English, Spanish, And French

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✏Vaccines Developed for Cancer Immunotherapy Book Summary : Vaccines have been successfully used for prophylaxis of infectious diseases for a long time and in the last decades have inspired researchers to make products with similar immunological mechanisms for cancer immunotherapy, which has been developed rapidly into clinical applications and has shown remarkable therapeutic efficacy, as exemplified by chimeric Ag receptor T cell (CAR-T cell) and immune checkpoint inhibitor-based therapies which can efficiently strengthen the body's immune system to fight against cancer, but they are also expensive. Therefore, encouraged by recent success of cancer immunotherapy, scientists are actively developing the low-cost tumor Ag-based vaccines, which, however, usually exhibit weak immunostimulating effects and, therefore, are often formulated with nanoparticulate carriers to form a vaccine adjuvant-delivery system (VADS), which can not only enhance the efficacy but also mitigate the off-target toxicity associated with conventional anticancer vaccines. These nanoparticulate carrier-based VADSs have demonstrated multiple functions, such as targetedly triggering Ag-presenting cells, reeducating tumor-associated macrophages (TAM) to function as tumor suppressor agent, and eliciting robust cytotoxic T lymphocytes (CTLs) to kill tumor cells. This chapter introduces multifunctional VADS that have been engineered with nanoparticulate carriers, including polymeric-, lipid-, metallic-, and cell-based nanoparticles, and used as an alternative to the existent tools for cancer immunotherapy.

Nkt Cells In Cancer Immunotherapy 2nd Edition Book PDF
✏Book Title : NKT Cells in Cancer Immunotherapy 2nd Edition
✏Author : Tonya J. Webb
✏Publisher : Frontiers Media SA
✏Release Date : 2020-11-20
✏Pages : 178
✏ISBN : 9782889661534
✏Available Language : English, Spanish, And French

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✏NKT Cells in Cancer Immunotherapy 2nd Edition Book Summary :

📒Cancer Immunology ✍ Nima Rezaei

Cancer Immunology Book PDF
✏Book Title : Cancer Immunology
✏Author : Nima Rezaei
✏Publisher : Springer Nature
✏Release Date :
✏Pages :
✏ISBN : 9783030502874
✏Available Language : English, Spanish, And French

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✏Cancer Immunology Book Summary :

Nk Cell Based Cancer Immunotherapy Book PDF
✏Book Title : NK Cell Based Cancer Immunotherapy
✏Author : Francisco Borrego
✏Publisher : Frontiers Media SA
✏Release Date : 2016-09-08
✏Pages :
✏ISBN : 9782889199341
✏Available Language : English, Spanish, And French

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✏NK Cell Based Cancer Immunotherapy Book Summary : Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expressed on target cells, such as the natural cytotoxicity receptors or NCRs (NKp30, NKp44 and NKp46), NKG2D, CD244 and DNAM-1. In addition, NK cells express Fc?RIIIA or CD16, the receptor that exerts antibody-dependent cell mediated cytotoxicity (ADCC). NK cells also express the death ligands FasL and TRAIL. The killing or sparing of target cells depends on the integration of distinct signals that originate from NK cell receptors. NK cells spare healthy cells that express normal levels of MHC class I molecules and low amounts of stress-induced self-molecules, whereas they kill target cells that down-regulate MHC class I molecules and/or up-regulate stress-induced self-molecules. The latter are common signatures of virus-infected cells and tumors. All the accumulated knowledge on NK cell biology, along with many clinical observations, is driving multiple efforts to improve the arsenal of NK cell-based therapeutic tools in the fight against malignant diseases. Indeed, NK cell-based immunotherapy is becoming a promising approach for the treatment of many cancers. It is well known that NK cells have a significant role in the anti-tumor effect of therapeutic antibodies that use ADCC as a mechanism of action. In addition to this, administration of autologous and allogeneic NK cells after activation and expansion ex vivo is used in the treatment of cancer. Moreover, adoptive transfer of NK cell lines has been tested in humans, and genetically modified NK cells expressing chimeric antigen receptors are being studied in preclinical models for potential use in the clinic.

Bioinformatics For Cancer Immunotherapy Book PDF
✏Book Title : Bioinformatics for Cancer Immunotherapy
✏Author : Sebastian Boegel
✏Publisher :
✏Release Date : 2020
✏Pages : 304
✏ISBN : 1071603272
✏Available Language : English, Spanish, And French

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✏Bioinformatics for Cancer Immunotherapy Book Summary : This volume focuses on a variety of in silico protocols of the latest bioinformatics tools and computational pipelines developed for neo-antigen identification and immune cell analysis from high-throughput sequencing data for cancer immunotherapy. The chapters in this book cover topics that discuss the two emerging concepts in recognition of tumor cells using endogenous T cells: cancer vaccines against neo-antigens presented on HLA class I and II alleles, and checkpoint inhibitors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Bioinformatics for Cancer Immunotherapy: Methods and Protocols is a valuable research tool for any scientist and researcher interested in learning more about this exciting and developing field.

Cancer Immunotherapy In Clinical Practice Book PDF
✏Book Title : Cancer Immunotherapy in Clinical Practice
✏Author : Michael M. Boyiadzis
✏Publisher : McGraw Hill Professional
✏Release Date : 2021-05-22
✏Pages : 624
✏ISBN : 9781259642050
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy in Clinical Practice Book Summary : A top-to-bottom overview of cancer immunotherapy–from basic science to clinical application The rapidly evolving field of immunotherapy is thoroughly and expertly covered in this cutting-edge text. Written by a world-renowned author team, this innovative resource provides readers with a solid grasp of the fundamental principles of basic immunology so they can better understand the medical uses of immunotherapy. The book then advances to practical application and toxicity management. Presented in a concise, templated, and easy-to-read format, Cancer Immunotherapy is the single-best resource for readers to familiarize themselves with the medical use of immunotherapy. The book includes an entire section on eighteen individual cancer types (brain, breast, etc.) with listings of approved drugs, information on each drug, and discussion of emerging therapies for each of the cancers. • Groundbreaking in that it is the first cancer immunology book to combine the basic science with actual clinical application • Includes the latest guidelines for immunotherapy, cancer immunotherapy, and toxicity management • Valuable opening section includes discussion of introduction to immunotherapy, components of the immune system, vaccines, the immune system in cancer, and more

Cancer Immunotherapy In Urology An Issue Of Urologic Clinics E Book Book PDF
✏Book Title : Cancer Immunotherapy in Urology An Issue of Urologic Clinics E Book
✏Author : Sujit S Nair
✏Publisher : Elsevier Health Sciences
✏Release Date : 2020-10-15
✏Pages : 240
✏ISBN : 9780323754996
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy in Urology An Issue of Urologic Clinics E Book Book Summary : The Guest Editors of this issue of Urologic Clinics of North America have put together a comprehensive collection of articles that provides the current knowledge on urologic cancer immunotherapy. Expert authors have contributed clinical review articles on the following topics: Era of personalized vaccines for GU cancers; TCR and dendritic vaccine platforms for GU cancers; Neo-adjuvant platforms for GU cancer immunotherapy; Immune-editing in Cancer: Role of tumor microenvironment and immune-suppressive pathways in localized and aggressive disease; Clinical integration of neo-adjuvant platforms for prostate cancer immunotherapy; Immunotherapy for muscle and non-muscle invasive bladder cancer: BCG and beyond; Immunotherapy for metastatic bladder cancer; Immunotherapy options for metastatic castrate-resistant prostate cancer; Role of tissue infiltrating lymphocytes: Understanding TCR; Therapeutic platforms for IPSC-derived CAR-T; Immune-suppression in prostate cancer: Underlying causes and influence on response to immunotherapy; and Racial disparity in response to immunotherapy. Urologists will come away with the most current information they need to improve outcomes in the urologic cancer patient.

📒Cancer Immunotherapy ✍ David B. Teplow

Cancer Immunotherapy Book PDF
✏Book Title : Cancer Immunotherapy
✏Author : David B. Teplow
✏Publisher : Academic Press
✏Release Date : 2019
✏Pages : 335
✏ISBN : OCLC:1112114468
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy Book Summary : Cancer Immunotherapy, Volume 164 in the Progress in Molecular Biology and Translational Science series, provides informative monographs on a variety of research topics related to different approaches to cancer immunotherapy, with this release focusing on TNFR2 in cancer immunology and immunotherapy, From the Hellstrom paradox towards cancer cure, CAR T-cell treatment of T-cell malignancy, Immunotherapy of pancreatic cancer, Cancer stem cell immunology/immunotherapy, Cytokine release syndrome, Tumor cell-based mechanisms of resistance to immune attack, and Mushroom compounds in cancer immunotherapy. --