Cancer Genomics

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  • Author : Graham Dellaire
  • Publisher : Academic Press
  • Pages : 510 pages
  • ISBN : 0123972744
  • Rating : /5 from reviews
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Download or Read online Cancer Genomics full in PDF, ePub and kindle. this book written by Graham Dellaire and published by Academic Press which was released on 21 November 2013 with total page 510 pages. We cannot guarantee that Cancer Genomics book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics. Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.

Cancer Genomics

Cancer Genomics
  • Author : Graham Dellaire,Jason N Berman,Robert J. Arceci
  • Publisher : Academic Press
  • Release : 21 November 2013
GET THIS BOOK Cancer Genomics

Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase

Cancer Genomics

Cancer Genomics
  • Author : Katayoon Kasaian,Yvonne Y. Li,Steven J.M. Jones
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOK Cancer Genomics

Advances in high-throughput sequencing technologies have enabled cost-effective sequencing of a single human genome at an unprecedented rate, facilitating scientific endeavours never imagined possible before. These improvements have transformed the field of cancer genomics, allowing the complete molecular characterization of individual cancer genomes. However, the promise of unveiling the complexity of cancer has lent itself to yet another level of complexity, the task of managing and integrating the massive amount of data that is generated as part of such experiments.

Illuminating Colorectal Cancer Genomics by Next Generation Sequencing

Illuminating Colorectal Cancer Genomics by Next Generation Sequencing
  • Author : Khalid El Bairi
  • Publisher : Springer Nature
  • Release : 28 September 2020
GET THIS BOOK Illuminating Colorectal Cancer Genomics by Next Generation Sequencing

This book reviews the potential of next-generation sequencing (NGS) in research on and management of colorectal cancer (CRC), a leading cause of death worldwide and one of the most biologically and clinically heterogeneous cancers. It critically discusses findings from recent large-scale studies, clinical trials and meta-analyses and offers an introduction to the management of CRC in the era of precision medicine. In CRC, dozens of driver and passenger mutations are associated with the malignant transformation of epithelial cells. Consequently, the

Cancer Genomics and Proteomics

Cancer Genomics and Proteomics
  • Author : Paul B. Fisher
  • Publisher : Humana Press
  • Release : 19 November 2010
GET THIS BOOK Cancer Genomics and Proteomics

Cancer Genomics and Proteomics provides a compendium of techniques and applications in gene identification and function. The approaches described in detail are state-of-the art and can be tailored to individual ongoing or planned research projects. This volume is a valuable laboratory resource for designing experiments to identify and analyze genes that are relevant to complex biological phenomena.

Cancer Genomics

Cancer Genomics
  • Author : Graham Dellaire,Robert J. Arceci
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOK Cancer Genomics

From the first descriptions of cancer in Egypt around 3000 BC to our current “one week” whole-genome sequence, the history of integrating new ideas into the practice of medicine has been unrelenting, although not without its failures as well its successes. This chapter represents a brief historical summary of some of the key success stories in our understanding of cancer that has led to our current age of cancer genomics. As the Chinese proverb states, “When you drink from the well,

Cancer Genomics for the Clinician

Cancer Genomics for the Clinician
  • Author : Ramaswamy Govindan, MD,Ashiq Masood, MD
  • Publisher : Springer Publishing Company
  • Release : 28 January 2019
GET THIS BOOK Cancer Genomics for the Clinician

Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips

Cancer Genomics

Cancer Genomics
  • Author : Hye-Jung E. Chun,Jaswinder Khattra,Martin Krzywinski,Samuel A. Aparicio,Marco A. Marra
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOK Cancer Genomics

Cancer results from accumulated mutations in the genome. Sequencing is an accurate method to detect mutations. Second-generation sequencing technology, commonly referred to as next-generation sequencing technology, enables rapid, efficient and affordable DNA sequencing, and is transforming the scale and scope of cancer research. The technology is sufficiently flexible and affordable to allow sequencing of many cancer genomes, and thus facilitates both sequencing of samples from large patient cohorts and during disease progression in individual cancer patients. The high depths of

Cancer Genomics

Cancer Genomics
  • Author : Ulrich Pfeffer
  • Publisher : Springer Science & Business Media
  • Release : 12 February 2013
GET THIS BOOK Cancer Genomics

The combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely

Cancer Genomics

Cancer Genomics
  • Author : Louise Parker
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOK Cancer Genomics

The number of people diagnosed with cancer each year will almost double to 21 million cases worldwide by 2030 because of the aging population. Studies of the human genome have demonstrated that as few as 5–10% of adult cancers are due to genetic inheritance. Over 90% of cancers are due to endogenous or exogenous exposure to chemicals and radiation; many of these carcinogenic exposures, to tobacco smoke, for example, are avoidable and thus the consequent disease is preventable. The “exposome” is the concept which

Cancer Genomics

Cancer Genomics
  • Author : Robert L. Strausberg
  • Publisher : IOS Press
  • Release : 19 October 2021
GET THIS BOOK Cancer Genomics

This work states that we are no longer satisfied to study a gene or gene product in isolation, but rather we strive to view each gene within the complex circuitry of a cell. It states that as a family of diseases, all cancer results from changes in the genome.

Cancer Genomics

Cancer Genomics
  • Author : Michael Fraser,Alejandro Berlin,Veronique Ouellet,Fred Saad,Robert G. Bristow
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOK Cancer Genomics

Prostate cancer (CaP) is the most commonly diagnosed malignancy in men in the Western world. In North America, more than 275000 men are diagnosed annually whereby approximately 1 in 6 men will be diagnosed with CaP in their lifetime, and 1 in 34 men will die from castrate-resistant metastatic disease. Unfortunately, current clinical prognostic factors explain only a proportion of the observed variation in clinical outcome from patient to patient. Furthermore, over-treatment of indolent and low-risk cancers leads to inappropriate morbidity following radiotherapy or surgery.

Cancer Genomics

Cancer Genomics
  • Author : Moamen Bydoun,Paola Marcato,Graham Dellaire
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOK Cancer Genomics

Breast cancer is the most common cancer in women worldwide and the second leading cause of cancer deaths. Although early diagnosis, outcome prediction and treatment options are the ultimate objectives when assessing breast cancer patients, the methodology behind this clinical assessment varies and has gradually evolved from using standard clinical criteria into incorporating high-throughput genome-wide analysis. Early methods involved evaluating tumor size and spread as well as histological assessment (tumor grade). Later, the expression of hormone/growth receptors (ER, PR,

Cancer Genomics

Cancer Genomics
  • Author : Daniel Gaston,Carman Giacomantonio
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOK Cancer Genomics

Colorectal cancer (CRC) is the third most common form of cancer and a leading cause of cancer-related mortality in both men and women, particularly in Western and developed nations. The high mortality rate has been attributed to the fact that colon cancer is often diagnosed at a late stage. Three primary subtypes of CRC have been described based on their molecular pathology and their underlying genetics: chromosomal instability (CIN), microsatellite instability (MSI), and CpG island hypermethylation. Over the last 30 years,

Cancer Genomics

Cancer Genomics
  • Author : Shahrad Rod Rassekh,Colin J.D. Ross
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOK Cancer Genomics

In the last 50 years, the cure rate for children with cancer has increased from 5–10% to over 80% today. However, this dramatic improvement in outcome has come at a significant cost. Approximately 40% of children suffer irreversible, life-threatening, or long-lasting toxicities that are caused by their medications during cancer treatment. Recent technological advances in genomics have opened the door to potentially identifying genetic differences between individual children that may explain their different responses to cancer therapies. The goals of the emerging field of

Cancer Genomics

Cancer Genomics
  • Author : Ryan D. Morin,Stephen B. Montgomery
  • Publisher : Elsevier Inc. Chapters
  • Release : 21 November 2013
GET THIS BOOK Cancer Genomics

Identifying gene expression changes in cancer provides opportunities to identify biomarkers that can be informative in regard to risk and in the choice of treatment options. In recent years, advances in sequencing have provided not only a quantitative measure of gene expression, but the resolution of diverse species of RNA, alternative transcripts and allele-specific expression. As well, such data have revealed novel sequences such as those from pathogens, mutations resulting in amino acid differences and fusion transcripts resulting from translocations