Biomarkers of Kidney Disease

• Author : Charles L. Edelstein
• Publisher : Academic Press
• Release : 08 November 2016

Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection, including metabolomics and proteomics are covered in the book. This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical

• Author : Vinood B. Patel
• Publisher : Springer
• Release : 11 March 2016

In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of

• Author : Mitchell H. Rosner,Mark Okusa
• Publisher : Nova Publishers
• Release : 23 March 2023

Advances in long-term improvement and outcomes of patients with kidney disease will require the use of novel biomarkers to identify patients at high risk for kidney disease and to diagnose kidney disease early for effective treatment. A biomarker is a substance found in the blood, body fluids or tissues that provides a measure of normal biological or pathological processes or response to pharmacological compounds or drugs. There are a wide variety of biomarkers including but not limited to mRNA, proteins

• Author : Joaquín García-Estañ,Felix Vargas
• Publisher : MDPI
• Release : 19 January 2021

This book provides important and updated information on current research devoted to urinary biomarkers. Urinary biomarkers are characteristics that can be objectively measured and evaluated as indicators of normal biological or pathogenic processes of pharmacological responses to therapeutic intervention.

• Author : Samuel N. Uwaezuoke
• Publisher : Unknown
• Release : 23 March 2023

Novel biomarkers are now used in the diagnostic and prognostic evaluation of common kidney diseases in children. The increased scientific interest in these biomarkers is partly due to the remarkable progress in their discovery techniques, and their validation in clinical subjects. However, the wide variation in their sensitivity and specificity is still a major concern. In the identification of biomarkers of kidney injury, an ideal biomarker should be produced after organ injury in concentrations which directly correlates with the degree

• Author : Seema S. Ahuja,Brian Castillo
• Publisher : Academic Press
• Release : 16 July 2020

Since laboratory testing and biomarkers are an integral part in the diagnosis and treatment of kidney disease, Kidney Biomarkers: Clinical Aspects and Laboratory Determination covers currently used biomarkers as well as markers that are in development. Laboratories are increasingly more involved in the follow-up confirmatory laboratory testing and this unique volume showcases the collaboration needed to solve diagnostic clinical puzzles between the laboratory and clinician. This volume provides guidance on laboratory test selection and results interpretation in patients. Sources of

• Author : Charles L. Edelstein
• Publisher : Academic Press
• Release : 27 October 2010

A biomarker is a molecule that is measured as a marker of normal biological processes, disease processes or the response to a diagnostic or therapeutic intervention. Kidney diseases like acute kidney injury, chronic kidney disease, diabetic nephropathy, glomerular disease, renal cancer and preeclampsia still have a high morbidity. Measurement of biomarkers in the blood or urine that detect patients at risk of kidney diseases or that detect kidney diseases in the earliest stage may ultimately result in preventative or earlier

• Author : J.A. Kellum,P.A. McCullough,R.L. Mehta,P.T. Murray,C. Ronco
• Publisher : Karger Medical and Scientific Publishers
• Release : 14 May 2013

Associated with both acute kidney injury (AKI) and cardio-renal syndromes (CRS), new biomarkers represent both a popular area of investigation and a new opportunity for advancement of therapy. This book contains the resolutions of the most recent ADQI conferences on biomarkers in AKI (Dublin) and on cardio-renal syndromes (Venice). The first part answers specific questions about new biomarkers and their use and utility in AKI: What are the most suitable candidate molecules and physiologic measures, how solid and evidence based

• Author : X. Ding,M.H. Rosner,C. Ronco
• Publisher : Karger Medical and Scientific Publishers
• Release : 23 January 2018

Acute Kidney Injury (AKI) is a complex syndrome that is prevalent among hospitalized patients. In recent years, occurrence of AKI events has risen due to a growing susceptibility of fragile and elderly subjects and an increase in the use of complex procedures such as cardiovascular surgery and imaging techniques. Exposure to potentially nephrotoxic drugs, such as new chemotherapeutic agents, is also proving to be a cause of AKI. This book summarizes recent advances in various settings. A reappraisal of current

• Author : John A. Kellum,C. Ronco,J. L. Vincent
• Publisher : Karger Medical and Scientific Publishers
• Release : 23 March 2023

A timely update Acute kidney injury (AKI) is a serious and as yet incompletely understood disorder in which sudden impairment of kidney function occurs secondary to one or more of a variety of underlying conditions. This disorder is very common in (elderly) ICU patients and is associated with very high mortality. Many of those who survive suffer from permanent kidney failure and other long-term morbidities, which may include cardiovascular disease and immune dysfunction. Epidemiologic evidence suggests that AKI is not

• Author : Helen Alderson
• Publisher : Unknown
• Release : 23 March 2023

• Author : Yoshio Terada,Takashi Wada,Kent Doi
• Publisher : Springer Nature
• Release : 14 May 2020

This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology,

• Author : Zainal Abedin
• Publisher : Unknown
• Release : 23 March 2023

• Author : Tan Laye Wah,King's College London. Department of Pharmacy
• Publisher : Unknown
• Release : 23 March 2023

Currently used procedures for the characterisation of renal disease are serum creatinine and blood urea nitrogen which only changes when 50% of renal function is lost. There is therefore an urgent need for more sensitive tests to detect drug nephrotoxicity and the early stages of renal disease. For example, drug induced AKI (acute kidney injury) could be reversible if biomarkers used serve as early detection for kidney injury and immediately discontinued the drug. -- This study focuses on developing a sensitive

• Author : Valérie Brunchault
• Publisher : Unknown
• Release : 23 March 2023

Early diagnosis of diseases is a big challenge to improve patients' health and quality of life. 'Omics' analyses, which allow the global and simultaneous quantification of the relative abundance of thousands of molecules in biological fluids are promising for the identification of early biomarkers of complex diseases. In this context, the objective of my thesis was to develop diagnostic tools, based on urinary peptidome and metabolome analyses, for the early detection of chronic kidney disease (CKD) and associated cardiovascular complications.