Biased Signaling in Physiology Pharmacology and Therapeutics

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  • Author : Brian J. Arey
  • Publisher : Academic Press
  • Pages : 316 pages
  • ISBN : 9780124114609
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Biased Signaling in Physiology Pharmacology and Therapeutics

Download or Read online Biased Signaling in Physiology Pharmacology and Therapeutics full in PDF, ePub and kindle. this book written by Brian J. Arey and published by Academic Press which was released on 17 June 2014 with total page 316 pages. We cannot guarantee that Biased Signaling in Physiology Pharmacology and Therapeutics book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

Biased Signaling in Physiology Pharmacology and Therapeutics

Biased Signaling in Physiology  Pharmacology and Therapeutics
  • Author : Brian J. Arey
  • Publisher : Academic Press
  • Release : 17 June 2014
GET THIS BOOK Biased Signaling in Physiology Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate

Biased Signaling in Physiology Pharmacology and Therapeutics

Biased Signaling in Physiology  Pharmacology and Therapeutics
  • Author : Brian J Arey
  • Publisher : Elsevier
  • Release : 05 June 2014
GET THIS BOOK Biased Signaling in Physiology Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate

GPCRs

GPCRs
  • Author : Beata Jastrzebska,Paul S.-H. Park
  • Publisher : Academic Press
  • Release : 11 September 2019
GET THIS BOOK GPCRs

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible

GPCRs

GPCRs
  • Author : Beata Jastrzebska,Paul S. H. Park
  • Publisher : Academic Press
  • Release : 01 October 2019
GET THIS BOOK GPCRs

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible

Pharmacology of G Protein Coupled Receptors

Pharmacology of G Protein Coupled Receptors
  • Author : S. J. Enna
  • Publisher : Academic Press
  • Release : 30 July 2021
GET THIS BOOK Pharmacology of G Protein Coupled Receptors

G protein coupled receptors remain the most important class of therapeutic targets in medicine. In the last 5 years, tremendous advances have been made in our understanding of the structure and mechanism of this critical family of drug targets. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors. It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological

Pharmacology and Therapeutics of Constitutively Active Receptors

Pharmacology and Therapeutics of Constitutively Active Receptors
  • Author : Ya-Xiong Tao
  • Publisher : Elsevier
  • Release : 11 June 2014
GET THIS BOOK Pharmacology and Therapeutics of Constitutively Active Receptors

Volume 70 of Advances in Pharmacology presents the pharmacology and therapeutics of constitutively active receptors. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists, and biochemists alike. Advances in Pharmacology provides a rich collection of reviews on timely topics. The series places emphasis on the molecular bases of drug action, both applied and experimental. Contributions from the best authors in the field An essential resource for pharmacologists, immunologists, and

Arrestins Pharmacology and Therapeutic Potential

Arrestins   Pharmacology and Therapeutic Potential
  • Author : Vsevolod V. Gurevich
  • Publisher : Springer Science & Business Media
  • Release : 29 November 2013
GET THIS BOOK Arrestins Pharmacology and Therapeutic Potential

This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.

Delta Opioid Receptor Pharmacology and Therapeutic Applications

Delta Opioid Receptor Pharmacology and Therapeutic Applications
  • Author : Emily M. Jutkiewicz
  • Publisher : Springer
  • Release : 27 September 2018
GET THIS BOOK Delta Opioid Receptor Pharmacology and Therapeutic Applications

This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role

Cannabinoid Pharmacology

Cannabinoid Pharmacology
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 18 August 2017
GET THIS BOOK Cannabinoid Pharmacology

Cannabinoid Pharmacology, Volume 80 is a new volume in the Advances in Pharmacology that presents reviews of recent breakthroughs. This volume aims to present current knowledge of the endogenous cannabinoid system, and looks at molecular, cellular, tissue and organismal effects of endogenous and exogenous cannabinoids. Topics of note in this new volume include Endocannabinoids and their congeners, Endocannabinoid turnover, Plant cannabinoids, Synthetic cannabinoids and ‘legal highs’, CB1 and CB2 cannabinoid receptors, Novel signaling modalities, Novel cannabinoid receptors, and Ion channel regulation

Physiology of Neurons

Physiology of Neurons
  • Author : Anne Feltz
  • Publisher : Garland Science
  • Release : 09 April 2020
GET THIS BOOK Physiology of Neurons

Thanks to tremendous technical advances in molecular biology and cellular imaging after those in electrophysiology, there is now a deep understanding of the physiology of nerve cells and their synaptic interconnections. The complexity of the brain emerges from the communication and interaction between billions of these elements. This book explores systematically and didactically the details of neuronal physiology, covering membrane biophysics, receptor physiology, sensory transduction and synaptic transmission with its selective pharmacology. Readers of the book will be fully equipped

Chemokines

Chemokines
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 24 February 2016
GET THIS BOOK Chemokines

Chemokines, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in chemokines, and includes sections on such topics as chemokine detection using receptors, tracking cellular responses to chemokines, recognition of GAG-bound chemokines, and the production of chemokine receptor complexes for structural and biophysical studies. Continues the legacy of this premier serial with quality chapters authored by leaders in the

Molecular and Cellular Physiology of Neurons Second Edition

Molecular and Cellular Physiology of Neurons  Second Edition
  • Author : Gordon L. Fain
  • Publisher : Harvard University Press
  • Release : 25 November 2014
GET THIS BOOK Molecular and Cellular Physiology of Neurons Second Edition

Gordon Fain’s Molecular and Cellular Physiology of Neurons, Second Edition is intended for anyone who seeks to understand nerve cell function: undergraduate and graduate students in neuroscience, students of bioengineering and cognitive science, and practicing neuroscientists who want to deepen their knowledge of recent discoveries.

Pharmacology and Therapeutics of Asthma and COPD

Pharmacology and Therapeutics of Asthma and COPD
  • Author : Clive P. Page,Peter J. Barnes
  • Publisher : Springer
  • Release : 06 February 2017
GET THIS BOOK Pharmacology and Therapeutics of Asthma and COPD

The present volume is supposed to be a major reference resource for chest physicians and those involved in the development of novel pharmaceutical entities for these diseases. Internationally recognized authorities review the most important new information on the advances in our understanding of the pathogenesis and treatment of these diseases, including the substantial advances in the topical delivery of inhaled medicines. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this