Basics Of Chimeric Antigen Receptor Car Immunotherapy

Basics Of Chimeric Antigen Receptor Car Immunotherapy Book PDF
✏Book Title : Basics of Chimeric Antigen Receptor CAR Immunotherapy
✏Author : Mumtaz Y. Balkhi
✏Publisher : Academic Press
✏Release Date : 2019-07-31
✏Pages : 92
✏ISBN : 9780128197479
✏Available Language : English, Spanish, And French

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✏Basics of Chimeric Antigen Receptor CAR Immunotherapy Book Summary : Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope that we may be on the verge of finally curing cancer. Over the years, huge progress has been made in controlling several stage IV metastasized cancers through the clinical application of checkpoint receptor inhibitory drugs and CAR-Therapy that has seen unprecedented interest in the immunotherapy field. Presents the first book to provide a basic understanding of chimeric antigen receptor (CARs) design, production and clinical application protocols Provides unique authority as the editor has worked directly with CARs Discusses the challenges encountered in actual clinical trials and how these challenges can be overcome Includes a full chapter on various challenges researchers should expect to encounter in the CAR-therapy field

Chimeric Antigen Receptor Car T Cell Immunotherapy For Muc1 Positive Breast Cancer Book PDF
✏Book Title : Chimeric Antigen Receptor CAR T cell Immunotherapy for MUC1 positive Breast Cancer
✏Author : Artemis Gavriil
✏Publisher :
✏Release Date : 2018
✏Pages :
✏ISBN : OCLC:1063625133
✏Available Language : English, Spanish, And French

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✏Chimeric Antigen Receptor CAR T cell Immunotherapy for MUC1 positive Breast Cancer Book Summary :

Part I Understanding Cancer Immunotherapy A Brief Review Part Ii What Is Chimeric Antigen Receptor Car T Cell Therapy An Emerging Cancer Treatment Modality  Book PDF
✏Book Title : Part I Understanding Cancer Immunotherapy A brief Review Part II What is Chimeric Antigen Receptor CAR T Cell Therapy An Emerging Cancer Treatment Modality
✏Author : Dr. Hakim Saboowala
✏Publisher : Dr.Hakim Saboowala
✏Release Date : 2020-05-12
✏Pages :
✏ISBN :
✏Available Language : English, Spanish, And French

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✏Part I Understanding Cancer Immunotherapy A brief Review Part II What is Chimeric Antigen Receptor CAR T Cell Therapy An Emerging Cancer Treatment Modality Book Summary : Part I- Understanding Cancer Immunotherapy: A brief Review. Immunotherapy, also called biologic therapy, is a type of cancer treatment that boosts the body's natural defenses to fight cancer. It uses substances made by the body or in a laboratory to improve or restore immune system function. Immunotherapy may work by: Stopping or slowing the growth of cancer cells Stopping cancer from spreading to other parts of the body Helping the immune system work better at destroying cancer cells There are several types of immunotherapy, including: Monoclonal antibodies and tumor-agnostic therapies Non-specific immunotherapies Oncolytic virus therapy T-cell therapy Cancer vaccines Part II- “What is Chimeric Antigen Receptor (CAR) T- Cell Therapy?” An Emerging Cancer Treatment Modality. Chimeric antigen receptor (CAR) T-cell therapy is an emerging cancer treatment modality in which the patients’ own immune cells are collected, genetically engineered to recognize a tumor-related target, expanded in vitro, and then reinfused to produce responses and prevent progression in a variety of malignancies (ie, adoptive cell transfer) Several types of adoptive cell transfer(ACT) are under investigation, but CAR T-cell therapy is the first to enter clinical practice. Like other technologies, CAR-T cell therapy has undergone a long development process in the past. Chimeric antigen receptor- (CAR-) T cell therapy is one of the most recent innovative immunotherapies and is rapidly evolving. At present, CAR-T cell therapy is developing rapidly, and many clinical trials have been established on a global scale, which has great commercial potential. I have endeavored to compile this E- Booklet into Two Parts i.e. Part I & Part II for better understanding of Chimeric antigen receptor (CAR) T-cell therapy, an emerging cancer treatment modality. In Part I, an effort has been made to describe Cancer Immunotherapy briefly whereas in Part II know about of CAR T-Cell Therapy-the first to enter clinical practice- has been embodied. Further it is attempted to describe toxicity of CAR-T cell therapy briefly and future development and opportunities for immunotherapy. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

Immunotherapy Using Chimeric Antigen Receptor Macrophage Book PDF
✏Book Title : Immunotherapy Using Chimeric Antigen Receptor Macrophage
✏Author : Peng Fei Huang
✏Publisher :
✏Release Date : 2019
✏Pages : 44
✏ISBN : OCLC:1089833443
✏Available Language : English, Spanish, And French

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✏Immunotherapy Using Chimeric Antigen Receptor Macrophage Book Summary : Chimeric antigen receptor (CAR) T cell immunotherapy has become one of the most prominent and leading cancer therapies due to its remarkable success in targeting hematological malignancies. Unfortunately, CAR-T cell immunotherapy has not had the same amount of success in solid tumors due to the challenging tumor's immunosuppressive microenvironment. Therefore, we hypothesize the use of macrophages as a vessel for CAR immunotherapy due to their associate with tumors as TAMs and also the tumors ability to secrete various chemokines that can attract myeloid cells to the tumor site. THP-1 a monocytic cell line that represents a monocyte/macrophage model was transduced with an anti-CD19 scFv CAR construct. K562 a leukemia cell line that represents hematological malignancies and H460 a lung cancer cell line that represents solid tumors were transduced to overexpress the surface marker CD19. THP-1 clones expressing the anti-CD19 CAR construct were cocultured with the two tumor cell lines, which demonstrated the ability of the THP-1 CARs to specifically targeted and lysis the tumor cells that overexpressed the CD19 surface marker. Upon CAR activation, THP-1 cells were polarized towards the M1 classical activated phenotype due to the increase in expression of TNF-[alpha], IL-1[beta], IL-6, IL-12[beta], CXCl10, HLA-DR, and CD86. Additionally, THP-1 cells did not show any change in the M2 alternative activated markers of IL10, TFG[beta], CCL18, CCL22, CD206, and CD204 to suggest polarization towards the M2 phenotype. As a result, this study validates the proof of concept that macrophages could potentially be a vessel for CAR immunotherapy.

Car T Cell Therapies For Non Hematopoietic Malignancies Taking Off The Training Wheels Book PDF
✏Book Title : CAR T Cell Therapies for Non Hematopoietic Malignancies Taking Off The Training Wheels
✏Author : Avery Dexter Posey, Jr.
✏Publisher : Frontiers Media SA
✏Release Date : 2020-04-24
✏Pages :
✏ISBN : 9782889636877
✏Available Language : English, Spanish, And French

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✏CAR T Cell Therapies for Non Hematopoietic Malignancies Taking Off The Training Wheels Book Summary : Chimeric antigen receptor (CAR) T cell therapies for leukemia (e.g. tisagenlecleucel) and lymphoma (e.g. axicabtagene ciloleucel) have recently received regulatory approval in the United States. Phase I/II trials have demonstrated complete remission of refractory or relapsed tumors in 50% - 94% patients. However, the clinical successes of engineered T cells for the treatment of solid malignancies have thus far been few and far between. Furthermore, several instances of severe and lethal toxicities have arisen due to on-target, off-tumor recognition of antigen by T cell products. Recent advances in phase I trials for solid tumors, as well as in pre-clinical models, have revealed several variables that will be important to consider for the successful use of CAR-T cells in treating solid tumors. These variables include (i) regional versus systemic delivery; (ii) scFv versus ligand interactions; (iii) antigen loss versus escape; (iv) epitope spreading and (v) checkpoint expression on immune cells or tumor cells. Also, there remains outstanding mechanistic questions related to why differences exist in the persistence and tonic signaling of second-generation CD28 versus 4-1BB co-stimulated CAR-T cells. In addition, we are now learning the roles of lympho-depleting regimens (and associated toxicities) in modifying the persistence of engineered T cell therapies. A more comprehensive view of CAR-T cell strategies and important advances, both of pre-clinical and clinical evaluations, in solid tumors is necessary to drive these therapies forward.

Targeting The Disialoganglioside Gd2 With Chimeric Antigen Receptor T Cells For Immunotherapy In Diffuse Midline Gliomas And Exploration Of Neuron Opc Synaptic Connectivity In The Context Of Adaptive Myelination Book PDF
✏Book Title : Targeting the Disialoganglioside GD2 with Chimeric Antigen Receptor T Cells for Immunotherapy in Diffuse Midline Gliomas and Exploration of Neuron opc Synaptic Connectivity in the Context of Adaptive Myelination
✏Author : Christopher Mount
✏Publisher :
✏Release Date : 2020
✏Pages :
✏ISBN : OCLC:1155251341
✏Available Language : English, Spanish, And French

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✏Targeting the Disialoganglioside GD2 with Chimeric Antigen Receptor T Cells for Immunotherapy in Diffuse Midline Gliomas and Exploration of Neuron opc Synaptic Connectivity in the Context of Adaptive Myelination Book Summary : Histone 3 K27M mutated diffuse midline glioma (H3K27M DMG) is a universally fatal pediatric brain tumor. Despite improved understanding of the molecular origins of this disease, translations to improvement in clinical outcomes have yet to materialize. To date, there has been little target exploration for immunotherapy applications in H3K27M DMG. In this thesis, I describe my work that elucidated substantial preclinical efficacy of chimeric antigen receptor (CAR)-bearing T cells targeting the disialoganglioside GD2 as an immunotherapy regimen in patient-derived orthotopic xenograft models of H3K27M DMG. Single-dose systemic administration of GD2-4-1BB-CAR T cells in multiple orthotopic xenograft models of H3K27M DMG achieves potent and lasting antitumor efficacy, including tumor clearance by in vivo bioluminescence imaging and follow-up histology. Treatment-associated toxicity was transient and generally tolerated during the period of peak anti-tumor activity in brainstem orthotopic xenografts. If these results are predictive of human response, GD2-directed CAR T cell therapy in the setting of careful clinical management could have a transformative impact upon H3K27M DMG outcomes. In part two of this thesis, I present data revealing a brain-wide map of afferent neuronal connectivity to oligodendrocyte precursor cells (OPCs). Neurons form bona fide synapses with oligodendrocyte precursor cells (OPCs), but the circuit context of these neuron to OPC synapses remains incompletely understood. Using monosynaptically-restricted rabies virus tracing of OPC afferents, I identified extensive afferent synaptic inputs to OPCs residing in secondary motor cortex and underlying corpus callosum of adult mice. These inputs primarily arise from functionally-interconnecting cortical areas and thalamic nuclei, demonstrating that OPCs in motor-associated territories have synaptic access to brain-wide projection networks engaged in planning and execution of motor tasks. This circuit map is a foundational tool for future studies of context-specific neuron-OPC synapse function.

📒Cancer Immunotherapy ✍ David B. Teplow

Cancer Immunotherapy Book PDF
✏Book Title : Cancer Immunotherapy
✏Author : David B. Teplow
✏Publisher : Academic Press
✏Release Date : 2019-08-03
✏Pages : 354
✏ISBN : 9780128165768
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy Book Summary : Cancer Immunotherapy, Volume 165 in the Progress in Molecular Biology and Translational Science series, provides informative monographs on a variety of research topics related to different approaches to cancer immunotherapy, with this release focusing on TNFR2 in cancer immunology and immunotherapy, From the Hellstrom paradox towards cancer cure, CAR T-cell treatment of T-cell malignancy , Immunotherapy of pancreatic cancer, Cancer stem cell immunology/immunotherapy, Cytokine release syndrome, Tumor cell-based mechanisms of resistance to immune attack, and Mushroom compounds in cancer immunotherapy. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Investigating The Efficacy Of Car T Cells Expressing Tqm 13 In Targeting Glioblastoma Book PDF
✏Book Title : Investigating the Efficacy of CAR T Cells Expressing TQM 13 in Targeting Glioblastoma
✏Author : Hali A Jiang
✏Publisher :
✏Release Date : 2019
✏Pages :
✏ISBN : OCLC:1107169324
✏Available Language : English, Spanish, And French

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✏Investigating the Efficacy of CAR T Cells Expressing TQM 13 in Targeting Glioblastoma Book Summary : Chimeric antigen receptor (CAR) modified T-cell therapy has proven to be an attractive immunotherapy that involves the genetic modification of T-lymphocytes to target specific antigens expressed by cancer cells. Recent research has shown promising results for CAR T-cells expressing Targeted Quadruple Mutant-13 (TQM-13), a mutant version of interleukin-13 (IL-13), in targeting and attacking glioblastoma multiforme (GBM). CAR T immunotherapy is able to utilize the inherent ability of T-lymphocyte cells to migrate across the blood-brain barrier (BBB), a specialized, highly selective, semipermeable membrane formed by neurovascular endothelial cells that restrict the substances that enter and exit the central nervous system. Additionally, the CAR modification leads to specialized targeting of a specific antigen displayed by the tumor of interest. Once attached and bound to the target, the CAR T-cell becomes activated leading to T-cell proliferation, secretion of apoptosis-inducing proteins, and subsequent destruction of the tumor cells. The present study examines the ability of CAR T-cells expressing TQM-13 to target GBM. The results indicate that CAR modification did not impede the cells natural ability to form intercellular gaps nor their ability to extravasate through an endothelial layer, both crucial steps in crossing the BBB. Additionally, it was found that CAR modification significantly increased both the total number of adhesions observed as well as the length of time the CAR T-cells adhered to GBM cells under flow conditions. These results imply that a TQM-13 directed CAR design has the potential to be a powerful therapeutic tool in the treatment of GBM.

Nk Cell Based Cancer Immunotherapy Book PDF
✏Book Title : NK Cell Based Cancer Immunotherapy
✏Author : Francisco Borrego
✏Publisher : Frontiers Media SA
✏Release Date : 2016-09-08
✏Pages :
✏ISBN : 9782889199341
✏Available Language : English, Spanish, And French

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✏NK Cell Based Cancer Immunotherapy Book Summary : Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expressed on target cells, such as the natural cytotoxicity receptors or NCRs (NKp30, NKp44 and NKp46), NKG2D, CD244 and DNAM-1. In addition, NK cells express Fc?RIIIA or CD16, the receptor that exerts antibody-dependent cell mediated cytotoxicity (ADCC). NK cells also express the death ligands FasL and TRAIL. The killing or sparing of target cells depends on the integration of distinct signals that originate from NK cell receptors. NK cells spare healthy cells that express normal levels of MHC class I molecules and low amounts of stress-induced self-molecules, whereas they kill target cells that down-regulate MHC class I molecules and/or up-regulate stress-induced self-molecules. The latter are common signatures of virus-infected cells and tumors. All the accumulated knowledge on NK cell biology, along with many clinical observations, is driving multiple efforts to improve the arsenal of NK cell-based therapeutic tools in the fight against malignant diseases. Indeed, NK cell-based immunotherapy is becoming a promising approach for the treatment of many cancers. It is well known that NK cells have a significant role in the anti-tumor effect of therapeutic antibodies that use ADCC as a mechanism of action. In addition to this, administration of autologous and allogeneic NK cells after activation and expansion ex vivo is used in the treatment of cancer. Moreover, adoptive transfer of NK cell lines has been tested in humans, and genetically modified NK cells expressing chimeric antigen receptors are being studied in preclinical models for potential use in the clinic.

The Immunobiology Of Hla Haploidentical Hematopoietic Cell Transplantation Book PDF
✏Book Title : The Immunobiology of HLA Haploidentical Hematopoietic Cell Transplantation
✏Author : Antonella Mancusi
✏Publisher : Frontiers Media SA
✏Release Date : 2020-07-03
✏Pages :
✏ISBN : 9782889638246
✏Available Language : English, Spanish, And French

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✏The Immunobiology of HLA Haploidentical Hematopoietic Cell Transplantation Book Summary :

Designing Chimeric Antigen Receptors To Effectively And Safely Target Tumors Book PDF
✏Book Title : Designing Chimeric Antigen Receptors to Effectively and Safely Target Tumors
✏Author :
✏Publisher :
✏Release Date : 2015
✏Pages :
✏ISBN : OCLC:1052001211
✏Available Language : English, Spanish, And French

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✏Designing Chimeric Antigen Receptors to Effectively and Safely Target Tumors Book Summary : Highlights: Description of structural elements of chimeric antigen receptors used to engineer T cells. Differences between T cell receptor and chimeric antigen receptor recognition. Types of T cells that can be engineered to target tumor cells. Strategies for augmenting function and selectivity of chimeric antigen receptors. Strategies for improving safety of chimeric antigen receptor modified T cells. Abstract : The adoptive transfer of T cells engineered to express artificial chimeric antigen receptors CARs) that target a tumor cell surface molecule has emerged as an exciting new approach for cancer immunotherapy. Clinical trials in patients with advanced B cell malignancies treated with CD19-specific CAR-modified T cells (CAR-T) have shown impressive antitumor efficacy, leading to optimism that this approach will be useful for treating common solid tumors. Because CAR-T cells recognize tumor cells independent of their expression of human leukocyte antigen (HLA) molecules, tumors that escape conventional T cells by downregulating HLA and/or mutating components of the antigen processing machinery can be eliminated. The ability to introduce or delete additional genes in T cells has the potential to provide therapeutic cell products with novel attributes that overcome impediments to immune mediated tumor elimination in immunosuppressive tumor microenvironments. This review will discuss recent concepts in the development of effective and safe synthetic CARs for adoptive T cell therapy (ACT).

T Cells Expressing Cd123 Chimeric Antigen Receptors For Treatment Of Acute Myeloid Leukemia Book PDF
✏Book Title : T Cells Expressing CD123 Chimeric Antigen Receptors for Treatment of Acute Myeloid Leukemia
✏Author :
✏Publisher :
✏Release Date : 2015
✏Pages :
✏ISBN : OCLC:1051335710
✏Available Language : English, Spanish, And French

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✏T Cells Expressing CD123 Chimeric Antigen Receptors for Treatment of Acute Myeloid Leukemia Book Summary : Abstract : Purpose of review: The purpose of this article is to discuss the rationale of targeting CD123 using chimeric antigen receptor (CAR) T cells for the treatment of leukemia. Recent findings: CD123 is a leukemia-associated antigen that expresses at high levels in leukemic stem cells and leukemic blasts and low level in normal hematopoietic stem/progenitor cells. Immune-based therapies targeting CD123 are being developed. Preclinical data suggest that CD123 CAR T cells exhibit potent antileukemic activity and various impacts on normal hematopoiesis. Summary: CD123 is an attractive surface target for novel antileukemic therapies. CD123 CAR T-cell-based immunotherapy is a promising treatment for patients with relapsed or refractory acute myeloid leukemia.

Chimeric Antigen Receptor T Cell Therapy For The Community Oncologist Book PDF
✏Book Title : Chimeric Antigen Receptor T Cell Therapy for the Community Oncologist
✏Author :
✏Publisher :
✏Release Date : 2016
✏Pages :
✏ISBN : OCLC:1053694839
✏Available Language : English, Spanish, And French

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✏Chimeric Antigen Receptor T Cell Therapy for the Community Oncologist Book Summary : Abstract : The field of cancer immunotherapy has rapidly progressed in the past decade as several therapeutic modalities have entered into the clinic. One such immunotherapy that has shown promise in the treatment of cancer is the use of chimeric antigen receptor (CAR)‐modified T lymphocytes. CARs are engineered receptors constructed from antigen recognition regions of antibodies fused to T‐cell signaling and costimulatory domains that can be used to reprogram a patient's T cells to specifically target tumor cells. CAR T‐cell therapy has demonstrated sustained complete responses for some patients with advanced leukemia, and a number of CAR therapies are being evaluated in clinical studies. CAR T‐cell therapy‐associated toxicities, including cytokine release syndrome, macrophage activation syndrome, and tumor lysis syndrome, have been observed and effectively managed in the clinic. In patients with significant clinical responses, sustained B‐cell aplasia has also been observed and is a marker of CAR T‐cell persistence that might provide long‐term disease control. Education on CAR T‐cell therapy efficacy and safety management is critical for clinicians and patients who are considering this novel type of treatment. In the present report, the current landscape of CAR T‐cell therapy, the effective management of patients undergoing treatment, and which patients are the most suitable candidates for current trials are discussed. Implications for Practice: The present report describes the current status of chimeric antigen receptor (CAR) T lymphocytes as an immunotherapy for patients with relapsed or refractory B‐cell malignancies. CAR T cells targeting CD19, a protein expressed on many B‐cell malignancies, typically induce high complete response rates in patients with B‐cell leukemia or lymphoma who have very limited therapeutic options. Recent clinical trial results of CD19 CAR T‐cell therapies and the management of CAR T‐cell‐associated adverse events are discussed. The present report will therefore inform physicians regarding the efficacy and safety of CAR T cells as a therapy for B‐cell malignancies. Abstract : An immunotherapy that has shown promise in cancer treatment is chimeric antigen receptor‐modified (CAR‐modified) T lymphocytes. CARs are engineered receptors constructed from antigen recognition regions of antibodies fused to T‐cell signaling and costimulatory domains that reprogram a patient's T cells to specifically target tumor cells. The current landscape of CAR T‐cell therapy, effective management of patients undergoing treatment, and the most suitable candidates for current trials are discussed.

Tumor Immunology And Immunotherapy Book PDF
✏Book Title : Tumor Immunology and Immunotherapy
✏Author : Robert C. Rees
✏Publisher : OUP Oxford
✏Release Date : 2014-05-29
✏Pages : 496
✏ISBN : 9780191664557
✏Available Language : English, Spanish, And French

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✏Tumor Immunology and Immunotherapy Book Summary : Patients are beginning to benefit from antibody based, cellular and vaccine approaches that are effective against genetically diverse and therapy-resistance cancers. BCG immunotherapy is now being used as a first line treatment for human bladder cancer and the introduction of prophylactic vaccination against Hepatitis B and HPV cancers is starting to show positive results. Following recent FDA approval for a vaccination against prostate cancer, and optimistic results in clinical trials for a vaccine targeting cancer antigens in lung cancer, cancer immunotherapy is now significantly impacting patient clinical management. Tumor Immunology and Immunotherapy provides an up-to-date and comprehensive account of cancer immunity and immunotherapy. It discusses our adaptive and innate immunity to cancer, the mechanisms underpinning our immune response, current approaches to cancer immunotherapy, and how tumour and host responses can circumvent effective anti-cancer immunity. The book examines recent results, publications and current areas of interest including 'immune editing' and the specific issues that are affecting the research and development of vaccines, providing insight into how these problems may be overcome, as viewed by world leaders in the field. Tumor Immunology and Immunotherapy will appeal to clinicians working in oncology and cancer immunotherapy, and research scientists including PhD and masters students, post-doctoral researchers and senior investigators.

Developments In T Cell Based Cancer Immunotherapies Book PDF
✏Book Title : Developments in T Cell Based Cancer Immunotherapies
✏Author : Paolo A. Ascierto
✏Publisher : Humana Press
✏Release Date : 2015-11-26
✏Pages : 305
✏ISBN : 9783319211671
✏Available Language : English, Spanish, And French

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✏Developments in T Cell Based Cancer Immunotherapies Book Summary : This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when adoptively transferred back to the patients. Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at improving their effectiveness as anti-cancer agents. Furthermore, the revolutionary role of checkpoint inhibitors and their potential in combination with other immunotherapeutic approaches or with standard chemo and radiation therapy are extensively discussed.

Defects In T Cell Trafficking And Resistance To Cancer Immunotherapy Book PDF
✏Book Title : Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy
✏Author : Emmanuel Donnadieu
✏Publisher : Springer
✏Release Date : 2016-08-30
✏Pages : 199
✏ISBN : 9783319422237
✏Available Language : English, Spanish, And French

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✏Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy Book Summary : This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

What Is Cytokine Release Syndrome Crs A K A Infusion Reaction Ir A Brief Review  Book PDF
✏Book Title : What is Cytokine Release Syndrome CRS a k a Infusion Reaction IR A Brief Review
✏Author : Dr. Hakim Saboowala
✏Publisher : Dr.Hakim Saboowala
✏Release Date : 2019-12-03
✏Pages : 31
✏ISBN :
✏Available Language : English, Spanish, And French

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✏What is Cytokine Release Syndrome CRS a k a Infusion Reaction IR A Brief Review Book Summary : During the last decade the field of cancer immunotherapy has witnessed impressive progress. Highly effective immunotherapies such as immune checkpoint inhibition and chimeric antigen receptor (CAR) T cells have shown remarkable efficacy in clinical trials and some of these agents have already received regulatory approval. However, along with growing experience in the clinical application of these potent immunotherapeutic agents comes the increasing awareness of their inherent and potentially fatal adverse effects, most notably the cytokine release syndrome (CRS). An attempt has been made as usual in this Booklet to provide a comprehensive review of the cytokine release syndrome (CRS) pathophysiology, risk factors, clinical presentation, differential diagnoses, management and future outlook etc. along with few illustrations and tables. …Dr.H.K.Saboowala.M.B.(Bom)M.R.S.H.(London)

Melanomas New Insights For The Healthcare Professional 2011 Edition Book PDF
✏Book Title : Melanomas New Insights for the Healthcare Professional 2011 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2012-01-09
✏Pages : 431
✏ISBN : 9781464900228
✏Available Language : English, Spanish, And French

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✏Melanomas New Insights for the Healthcare Professional 2011 Edition Book Summary : Melanomas: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Melanomas. The editors have built Melanomas: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Melanomas in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Melanomas: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Natural Killer Cells The Future Of Cancer Immunotherapy Book PDF
✏Book Title : Natural Killer Cells the Future of Cancer Immunotherapy
✏Author : Priyanka Senthil
✏Publisher :
✏Release Date : 2020-04-20
✏Pages : 53
✏ISBN : 9798638783372
✏Available Language : English, Spanish, And French

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✏Natural Killer Cells the Future of Cancer Immunotherapy Book Summary : Cellular therapeutics is an emerging field with significant advances in the engineering of immune effector cells that play a revolutionary role in treatment for cancer. Up until now, most immunomodulatory strategies focus on enhancing T cells, which are lymphocyte immune cells that are important for cell-mediated immunity to fight pathogens and cancer. T cells have proven their ability in successful cellular therapies against leukemia, but may soon face competition. Through several preclinical studies, researchers have discovered new guardian immune cells called chimeric antigen receptor-modified natural killer (CAR NK) cells that have been genetically engineered to produce an artificial T-cell receptor for use in immunotherapy. With chimeric antigen receptors (CARs), CAR NK cells can specifically recognize antigen-expressing tumors and show cytotoxic activity against various solid tumor types. Natural killer (NK) cells target cells that lack expression of major histocompatibility complex (MHC) class I like tumors and virus-infected cells. The preclinical evidence suggests that NK cells have the same cancer-homing receptors as T cells and the ability to effectively recognize and kill targets through genetic modification. However, for the cell to be effective, scientists need to provide antigen specificity, for which they have found strategies to introduce CARs into NK cells and cell lines. If scientists can overcome the challenge of properly manufacturing engineered NK cells, CAR NK cells could be safer, cheaper, easier to produce, and more widely applicable than T cells. This book focuses on recent advances in NK cell engineering and discusses how NK cells contribute to new immunotherapeutic approaches for treatment against refractory hematological malignancies.

Hematopoietic Stem Cell Derived Chimeric Antigen Receptor Expressing Cells Traffic To Hiv Reservoir Sites In Shiv Infected Non Human Primates Book PDF
✏Book Title : Hematopoietic Stem Cell derived Chimeric Antigen Receptor Expressing Cells Traffic to HIV Reservoir Sites in SHIV infected Non human Primates
✏Author : Isaac M. Barber-Axthelm
✏Publisher :
✏Release Date : 2019
✏Pages : 126
✏ISBN : OCLC:1117469200
✏Available Language : English, Spanish, And French

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✏Hematopoietic Stem Cell derived Chimeric Antigen Receptor Expressing Cells Traffic to HIV Reservoir Sites in SHIV infected Non human Primates Book Summary : The successful treatment of 2 HIV+ individuals with allogeneic stem cell transplantations has garnered much interest in its utility as a therapy for HIV. However, there are significant limitations that prevent allogeneic stem cell transplantation from being a viable therapy for HIV infection, including toxicity due to Graft-versus-host disease, and the limited availability of donors who are homozygous for the CCR5[delta]32 mutation. One viable option to circumvent these limitations and provide a functional cure, through immune-mediated elimination of the virus, is with chimeric antigen receptor (CAR) immunotherapy. By introducing the CAR engineered to target HIV infected cells into hematopoietic stem cells, we have the potential to generate a self-renewing population of CAR T-cells, thus circumventing some of the limitations with longevity that are seen with CAR T-cells. Here, we report trafficking of hematopoietic stem and progenitor (HSPC)-derived CAR+ cells to HIV tissue reservoir sites, in a pigtail macaque model of HIV infection. CAR+ cells were identified in the lymphoid germinal centers, the parenchyma of the central nervous system, and the gastrointestinal tract by immunohistochemistry, almost 2 years after initial engraftment with lentiviral modified HSPCs. Multilineage engraftment of CAR+ cells were identified in lymphoid germinal centers and the gastrointestinal tract, consisting of T-cells, B-cells, and myeloid lineage cells. CAR+ B-cells in the germinal centers were also actively replicating, characterized by robust Ki-67 expression. No difference was observed in trafficking, engraftment, and cell cycle activity between CAR animals and control animals that carry a "tailless" CAR which lacks the cytoplasmic signal transduction domain. These results show the HSPC-derived CAR+ cells will traffic to, and persist in, HIV tissue reservoir sites, with multilineage engraftment of CAR+ cells. The method could be used as a platform for immunotherapeutic delivery treatment of HIV infection, as well as a variety of other medical conditions.

Malignant Gliomas Rmr V3 I2 Book PDF
✏Book Title : Malignant Gliomas RMR V3 I2
✏Author :
✏Publisher : Demos Medical Publishing
✏Release Date : 2012-10-09
✏Pages : 252
✏ISBN : 9781617051487
✏Available Language : English, Spanish, And French

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✏Malignant Gliomas RMR V3 I2 Book Summary : Radiation Medicine Rounds is a trinary, hard cover periodical designed to provide an up-to-date review of a dedicated radiation medicine topic of interest to clinicians and scientists who are involved in the care of patients receiving radiotherapy. It is intended to serve as both a reference and instructional tool for students, housestaff, fellows, practicing clinicians, medical physicists, cancer biologists, radiobiologists, and interdisciplinary colleagues throughout the oncology spectrum. This issue of Radiation Medicine Rounds discusses the more salient topics surrounding the role of radiation therapy for malignant gliomas. The specialty of radiation therapy has increased in complexity over the years, yet as technology improves, the goal of improving outcomes while decreasing toxicity remains critical. Malignant gliomas remain among the most devastating of all malignancies, yet as conventional treatments (surgery, radiation, and chemotherapy) have become optimized overall survival has improved. The underlying molecular and genetic mechanisms of these tumors are becoming better understood, with one of the most important realizations being that histopathologically identical malignant gliomas often demonstrate very distinct clinical behaviors. Malignant Gliomas provides the practitioner with a current overview of best practices, recent research, and future directions in the management of this complex and challenging cancer.

Current Perspectives Challenges And Advances In Cell Based Therapies Book PDF
✏Book Title : Current Perspectives Challenges and Advances in Cell Based Therapies
✏Author : Prashant Trikha
✏Publisher : Frontiers Media SA
✏Release Date : 2020-03-24
✏Pages :
✏ISBN : 9782889635641
✏Available Language : English, Spanish, And French

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✏Current Perspectives Challenges and Advances in Cell Based Therapies Book Summary :

Modern Management Of High Grade Glioma Part Ii An Issue Of Neurosurgery Clinics E Book Book PDF
✏Book Title : Modern Management of High Grade Glioma Part II An Issue of Neurosurgery Clinics E Book
✏Author : Isaac Yang
✏Publisher : Elsevier Health Sciences
✏Release Date : 2012-07-15
✏Pages : 240
✏ISBN : 9781455747689
✏Available Language : English, Spanish, And French

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✏Modern Management of High Grade Glioma Part II An Issue of Neurosurgery Clinics E Book Book Summary : Standard therapy for high grade glioma is a topic that is evolving, timely, and relevant. Guest Editors Isaac Yang, MD and Seunggu Han, MD have assembled a group of experts on management of high grade glioma. Some of the articles in this issue include: Use of language mapping to aid resection of eloquent gliomas; Clinical trials with immunotherapy; Clinical trials for small molecule inhibitors; Nanotechnology potential applications for GBM therapy; High Grade Gliomas in children; Modern Advances in Brain Tumor Treatments; Molecular pathways of Avastin interactions for the treatment of glioblastoma; and Quality of Life and Outcomes in Glioblastoma management.

Cancer New Insights For The Healthcare Professional 2011 Edition Book PDF
✏Book Title : Cancer New Insights for the Healthcare Professional 2011 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2012-01-09
✏Pages : 3937
✏ISBN : 9781464900020
✏Available Language : English, Spanish, And French

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✏Cancer New Insights for the Healthcare Professional 2011 Edition Book Summary : Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Impact Of Immunotherapy In The Treatment Of Glioblastoma Book PDF
✏Book Title : Impact of Immunotherapy in the Treatment of Glioblastoma
✏Author : Jessica Silva
✏Publisher :
✏Release Date : 2018
✏Pages :
✏ISBN : OCLC:1154234821
✏Available Language : English, Spanish, And French

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✏Impact of Immunotherapy in the Treatment of Glioblastoma Book Summary : Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor. Despite the efforts developed in the respective treatment, consisting of maximal surgical resection followed by adjuvant radiotherapy and chemotherapy, the prognosis remains very poor. This may be partly related to the resistance of GBM cells and their infiltrative and invasive nature into the surrounding brain tissue. Therefore, newer and challenging alternative approaches for the treatment have emerged, including immunotherapy. This anticancer therapy, based on the stimulation of the host's immune system, has been currently investigated and several advances in the clinical trial stage have already been reached. Immunotherapeutic strategies comprise a set of modalities, including vaccines (cell-free and cell-based), chimeric antigen receptor (CAR) T-cell therapy, immune checkpoint inhibitors, monoclonal antibodies (mAbs), and oncolytic viruses (OVs). In this chapter, we will review the principal concepts and the recent progress in immunotherapy for GBM.

Engineering Molecular Modules Through Directed Evolution For Applications In Single Cell Imaging And Immunotherapy Book PDF
✏Book Title : Engineering Molecular Modules Through Directed Evolution for Applications in Single Cell Imaging and Immunotherapy
✏Author : Praopim Limsakul
✏Publisher :
✏Release Date : 2019
✏Pages : 112
✏ISBN : OCLC:1090808482
✏Available Language : English, Spanish, And French

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✏Engineering Molecular Modules Through Directed Evolution for Applications in Single Cell Imaging and Immunotherapy Book Summary : Protein engineering through directed evolution has been extensively used to improve and modify the structure and function of proteins for wide range of applications. In this dissertation, I utilized the conventional directed evolution through yeast surface display library to engineer a single molecular module, i.e., monobody to have high binding affinity to R-Phycoerythrin. This engineered monobody was then applied to 1) a FRET biosensor with improved spatial resolution to monitor biological process of cancer cell invasion, and 2) a universal chimeric antigen receptor (CAR) for cancer immunotherapy. To further extend the power of directed evolution, I combined it with other technologies, including mammalian cell library, functional screening by FACS-based FRET, high-throughput DNA sequencing, and sequence-function analysis, to systematically optimize the sensitivity, specificity, and dynamic range of the FRET biosensors for monitoring kinase activities with high spatiotemporal resolution in living cells. These optimized biosensors can be used to study the cell signaling of CAR T cells upon engagement with cancer cells to improve the efficiency of CAR T cell immunotherapy. Overall, this dissertation illustrates the potential of directed evolution as a tool to engineer the molecular modules/sensors for biomedical diagnosis and immunotherapy.

Current Immunotherapeutic Strategies In Cancer Book PDF
✏Book Title : Current Immunotherapeutic Strategies in Cancer
✏Author : Matthias Theobald
✏Publisher : Springer Nature
✏Release Date : 2019-08-31
✏Pages : 187
✏ISBN : 9783030237653
✏Available Language : English, Spanish, And French

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✏Current Immunotherapeutic Strategies in Cancer Book Summary : This book offers a comprehensive review of recent advances in cancer immunotherapy, and explores the value and limitations of the most effective current therapeutic strategies and emerging treatment modalities. It discusses in detail the successes achieved using monoclonal antibodies (mAbs), including developments with regard to conjugated mAbs and also bispecific mAbs as novel treatment options for leukemia and solid tumors. It also examines the advances toward personalized immunotherapy, focusing on the effectiveness of adoptive cell therapy using genetically engineered T cells with tumor-associated antigen-specific T-cell receptors and chimeric antigen receptors, as well as the role of tailored vaccines based on the patient’s cancer mutanome. Further, it describes the impressive therapeutic results recently achieved with checkpoint inhibitors, and analyzes novel strategies to modulate the immunosuppressive tumor microenvironment. Written by leading international experts and providing up-to-date information on emerging strategies, such as oncolytic virus-based therapy, epigenetic therapy, and combination therapy, the book appeals to all those with an interest in immunotherapy as it comes of age.

Childhood Leukemia And Cancer An Issue Of Pediatric Clinics E Book Book PDF
✏Book Title : Childhood Leukemia and Cancer An Issue of Pediatric Clinics E Book
✏Author : Yaddanapudi Ravindranath
✏Publisher : Elsevier Health Sciences
✏Release Date : 2014-12-26
✏Pages : 353
✏ISBN : 9780323354660
✏Available Language : English, Spanish, And French

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✏Childhood Leukemia and Cancer An Issue of Pediatric Clinics E Book Book Summary : This issue concentrates on the current evidence and the collected experience of pediatric oncologists who care for cancer patients. The individual articles will provide the general pediatrician with a comprehensive primer on diagnosing and managing various types of cancers in the child with cancer. A cancer diagnosis is no longer a death sentence, so management and monitoring is very important and covered in every article.

Cancer Immunotherapy Immuno Monitoring Mechanism Treatment Diagnosis And Emerging Tools Book PDF
✏Book Title : Cancer Immunotherapy Immuno monitoring Mechanism Treatment Diagnosis and Emerging Tools
✏Author : Chao Ma
✏Publisher : Frontiers E-books
✏Release Date : 2014-12-16
✏Pages :
✏ISBN : 9782889193806
✏Available Language : English, Spanish, And French

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✏Cancer Immunotherapy Immuno monitoring Mechanism Treatment Diagnosis and Emerging Tools Book Summary : In the past decade, significant progresses have taken place in the field of cancer immunotherapy. Tumor-targeting immunotherapies are being developed for most human cancers, including melanoma, prostate cancer, glioblastoma, sarcoma, lung carcinoma and hepatocellular carcinoma. The FDA has approved multiple molecular immunotherapeutics, such as Ipilimumab; cellular immunotherapies (e.g. adoptive cell transfer) are being tested in phase II/III clinical trials. Immunotherapetics has evolved into a sophisticated field: Multimodal therapeutic regimens are administrated to induce focused responses, curtail side- effects and improve therapeutic efficacy. The lack of effective clinical assessment tools remains a major challenge. Because of the intricacy of antitumor response, it is essential to scrutinize individual tumor-targeting immune cells and their functions at the finest details – molecules. In this regard, flow cytometry analysis modernized hematology and allows characterization of surface molecular signature on individual cells. More recently, microchip technologies and new variations of cytometry have enormously expanded the spectrum, throughout and multiplexity of single cell analysis. Nowadays, tens of millions of readouts can be generated through the course of a cancer immunotherapy to monitor the abundance, phenotype and a myriad of effector functions of single immune cells. At the same time, big data analytics and data mining methodologies have been adapted to achieve sensible diagnostic interpretations. Such a marriage of technology and analytics opens the door for informative point-of-care assessment of therapeutic efficacy and ensures timely therapeutic decisions. The new generation of personalized clinical diagnostics will revolutionize healthcare in the years to come.

Neuroblastomas New Insights For The Healthcare Professional 2011 Edition Book PDF
✏Book Title : Neuroblastomas New Insights for the Healthcare Professional 2011 Edition
✏Author :
✏Publisher : ScholarlyEditions
✏Release Date : 2012-01-09
✏Pages : 152
✏ISBN : 9781464901751
✏Available Language : English, Spanish, And French

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✏Neuroblastomas New Insights for the Healthcare Professional 2011 Edition Book Summary : Neuroblastomas: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neuroblastomas. The editors have built Neuroblastomas: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuroblastomas in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Neuroblastomas: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.