Basic Principles of Drug Discovery and Development

Produk Detail:
  • Author : Benjamin E. Blass
  • Publisher : Academic Press
  • Pages : 712 pages
  • ISBN : 0128172150
  • Rating : /5 from reviews
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Download or Read online Basic Principles of Drug Discovery and Development full in PDF, ePub and kindle. this book written by Benjamin E. Blass and published by Academic Press which was released on 25 May 2021 with total page 712 pages. We cannot guarantee that Basic Principles of Drug Discovery and Development book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry

Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development
  • Author : Benjamin E. Blass
  • Publisher : Academic Press
  • Release : 25 May 2021
GET THIS BOOK Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and

Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development
  • Author : Benjamin Blass
  • Publisher : Academic Press
  • Release : 28 April 2015
GET THIS BOOK Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : C. Robin Ganellin,Roy Jefferis,Stanley M. Roberts
  • Publisher : Academic Press
  • Release : 07 May 2013
GET THIS BOOK Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the

Oral Bioavailability

Oral Bioavailability
  • Author : Xiaoling Li
  • Publisher : John Wiley & Sons
  • Release : 04 August 2011
GET THIS BOOK Oral Bioavailability

Understand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability. The difference in rate and extent between a drug taken orally and the

Mass Spectrometry in Drug Metabolism and Disposition

Mass Spectrometry in Drug Metabolism and Disposition
  • Author : Mike S. Lee,Mingshe Zhu
  • Publisher : John Wiley & Sons
  • Release : 16 March 2011
GET THIS BOOK Mass Spectrometry in Drug Metabolism and Disposition

This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets

General and Molecular Pharmacology

General and Molecular Pharmacology
  • Author : Francesco Clementi,Guido Fumagalli
  • Publisher : John Wiley & Sons
  • Release : 01 July 2015
GET THIS BOOK General and Molecular Pharmacology

With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for

Drug Discovery and Development

Drug Discovery and Development
  • Author : Raymond G. Hill,H. P. Rang
  • Publisher : Churchill Livingstone
  • Release : 25 September 2021
GET THIS BOOK Drug Discovery and Development

The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries' trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories

Drug Discovery and Development Volume 1

Drug Discovery and Development  Volume 1
  • Author : Mukund S. Chorghade
  • Publisher : Wiley-Interscience
  • Release : 16 June 2006
GET THIS BOOK Drug Discovery and Development Volume 1

This two volume set provides a comprehensive account of the entire sequence of operations involved in discovering a drug through the actual delivery of the drug to clinicians and medical practitioners. Includes case studies of the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil) Discusses the discovery of agents for the treatment and management of bacterial infections, Parkinson's disease, psoriasis, ulcers and stomach pain, atopic dermatitis, asthma, and cancer Contains chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics,

Pharmacokinetics in Drug Discovery and Development

Pharmacokinetics in Drug Discovery and Development
  • Author : Ronald D. Schoenwald
  • Publisher : CRC Press
  • Release : 06 March 2002
GET THIS BOOK Pharmacokinetics in Drug Discovery and Development

Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Fulfilling the need for a wide-ranging guide to the many existing subspecialties in this field, Pharmacokinetics in Drug Discovery and Development details the different areas in the field providing the ideal comprehensive, quick access text and reference. After an

Drug Discovery and Development Volume 2

Drug Discovery and Development  Volume 2
  • Author : Mukund S. Chorghade
  • Publisher : John Wiley & Sons
  • Release : 16 February 2007
GET THIS BOOK Drug Discovery and Development Volume 2

From first principles to real-world applications-here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview

Chemical Biology

Chemical Biology
  • Author : Natanya Civjan
  • Publisher : John Wiley & Sons
  • Release : 07 August 2012
GET THIS BOOK Chemical Biology

An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from

Pharmacokinetics and Metabolism in Drug Design

Pharmacokinetics and Metabolism in Drug Design
  • Author : Dennis A. Smith,Han van de Waterbeemd,Don K. Walker
  • Publisher : John Wiley & Sons
  • Release : 21 August 2006
GET THIS BOOK Pharmacokinetics and Metabolism in Drug Design

In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything

Cancer Drug Design and Discovery

Cancer Drug Design and Discovery
  • Author : Stephen Neidle
  • Publisher : Academic Press
  • Release : 30 September 2013
GET THIS BOOK Cancer Drug Design and Discovery

Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several sections on the basic and applied science of cancer drug discovery and features those drugs that are now approved for human use and

Lysosomes

Lysosomes
  • Author : Frederick R. Maxfield,James M. Willard,Shuyan Lu
  • Publisher : John Wiley & Sons
  • Release : 22 June 2016
GET THIS BOOK Lysosomes

Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and

The Future of Pharmaceutical Product Development and Research

The Future of Pharmaceutical Product Development and Research
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 19 August 2020
GET THIS BOOK The Future of Pharmaceutical Product Development and Research

The Future of Pharmaceutical Product Development and Research examines the latest developments in the pharmaceutical sciences, also highlighting key developments, research and future opportunities. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of the product development phase of drug discovery and drug development. Each chapter covers fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and the pharmaceutical industry. The book focuses on excipients, radiopharmaceuticals,