Background Lesions in Laboratory Animals E Book

• Author : Elizabeth Fiona McInnes
• Publisher : Elsevier Health Sciences
• Release : 24 October 2011

Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared

• Author : Elizabeth Fiona McInnes
• Publisher : Saunders Limited
• Release : 07 June 2023

Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared

• Author : Elizabeth McInnes
• Publisher : John Wiley & Sons
• Release : 01 May 2017

Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study

• Author : Cynthia P. Smith,Victoria Taylor
• Publisher : DIANE Publishing
• Release : 01 November 1996

Covers psychological well-being, ecological, or behavioral needs of animals. These are essential requirements, not luxuries. Sections: articles and bibliographies; journal listing and subscription information; organizations (North Amer. resources; European, Asian, and Australian resources); suppliers and products; and common devices and programs. Each section is introduced by a paper which provides general background information on the biology of the animals and their currently accepted needs in captivity. Extensive subject index.

• Author : Cheryl L. Scudamore
• Publisher : John Wiley & Sons
• Release : 10 February 2014

A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year. Complete phenotypic analysis of all of these models can benefit from histologic review of the tissues. This book is aimed at veterinary and medical pathologists who are unfamiliar with mouse tissues and scientists who wish to evaluate their own mouse models. It provides practical

• Author : Elizabeth McInnes
• Publisher : John Wiley & Sons
• Release : 01 May 2017

Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study

• Author : Steve Gilbert,Asish Mohapatra,Sol Bobst,Antoinette Hayes,Sara T. Humes
• Publisher : Academic Press
• Release : 16 May 2020

This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world

• Author : John P. Sundberg,Peter Vogel,Jerrold M. Ward
• Publisher : John Wiley & Sons
• Release : 26 January 2022

An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and

• Author : Pritam S. Sahota,James A. Popp,Jerry F. Hardisty,Chirukandath Gopinath,Page Bouchard
• Publisher : CRC Press
• Release : 14 August 2018

Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk. Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new

• Author : Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer
• Publisher : Academic Press
• Release : 13 March 2015

The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity

• Author : Ali S. Faqi
• Publisher : Academic Press
• Release : 02 November 2012

A Comprehensive Guide to Toxicology in Preclinical Drug Development is designed for toxicologists who need a thorough understanding of the drug development process. This multi-contributed reference will provide a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. Intended as a comprehensive resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations (CRO), this book will discuss discovery toxicology and the international guidelines for

• Author : Andrew W. Suttie,Joel R. Leininger,Alys E. Bradley
• Publisher : Academic Press
• Release : 18 December 2017

Boorman’s Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm,

• Author : Pritam S. Sahota,Robert H. Spaet,Philip Bentley,Zbigniew Wojcinski
• Publisher : CRC Press
• Release : 26 April 2019

There has been a growing interest in toxicologic pathology, especially as related to its impact on the safety assessment of pharmaceuticals and chemicals, and in drug development. Thus, there is a growing need for an Illustrated Dictionary of Toxicology Pathology and Safety Science (IDTP) that this dictionary aims to fill. The language of toxicologic pathology may be less familiar to a broad range of safety scientists, especially those involved in the safety evaluation of pharmaceuticals and chemicals. The IDTP format

• Author : Thomas J. Steinbach,Daniel J. Patrick,Mary Ellen Cosenza
• Publisher : Springer Nature
• Release : 31 October 2019

This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general

• Author : David M. Kurtz,Gregory S. Travlos
• Publisher : CRC Press
• Release : 18 October 2017

Key features: Serves as the detailed, authoritative source of the clinical chemistry of the most commonly used laboratory animals Includes detailed chapters dedicated to descriptions of clinical chemistry-related topics specific to each laboratory species as well as organ/class-specific chapters Presents information regarding evaluation and interpretation of a variety of individual clinical chemistry end points Concludes with detailed chapters dedicated to descriptions of statistical analyses and biomarker development of clinical chemistry-related topics Provides extensive reference lists at the end of