Astrocytes and Epilepsy

Produk Detail:
  • Author : Jacqueline A. Hubbard
  • Publisher : Academic Press
  • Pages : 394 pages
  • ISBN : 0128026243
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Astrocytes and Epilepsy

Download or Read online Astrocytes and Epilepsy full in PDF, ePub and kindle. this book written by Jacqueline A. Hubbard and published by Academic Press which was released on 05 July 2016 with total page 394 pages. We cannot guarantee that Astrocytes and Epilepsy book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Astrocytes and Epilepsy

Astrocytes and Epilepsy
  • Author : Jacqueline A. Hubbard,Devin K. Binder
  • Publisher : Academic Press
  • Release : 05 July 2016
GET THIS BOOK Astrocytes and Epilepsy

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of

Crucial Role for Astrocytes in Epilepsy

Crucial Role for Astrocytes in Epilepsy
  • Author : Peter Bedner,Christian Steinhäuser
  • Publisher : Biota Publishing
  • Release : 01 August 2015
GET THIS BOOK Crucial Role for Astrocytes in Epilepsy

This book summarizes current evidence of astrocyte dysfunction in epilepsy and discusses presumed underlying mechanisms. Epilepsy is characterized by the periodic occurrence of seizures. Currently available anticonvulsant drugs and therapies are insufficient to controlling seizures in about one third of patients. Thus, there is an urgent need for new therapies that prevent generation of the disorder and improve seizure control in individuals already afflicted. The vast majority of epileptic cases are of idiopathic origin with their underlying mechanisms being unclear.

Examining the Role of Astrocyte Swelling and Swelling induced Glutamate Release in Two Models of Neuronal Hyperexcitability

Examining the Role of Astrocyte Swelling and Swelling induced Glutamate Release in Two Models of Neuronal Hyperexcitability
  • Author : Thomas Robert Murphy
  • Publisher : Unknown
  • Release : 18 September 2021
GET THIS BOOK Examining the Role of Astrocyte Swelling and Swelling induced Glutamate Release in Two Models of Neuronal Hyperexcitability

Epilepsy, a spectrum of over 40 different disorders, is estimated to affect 1 in 26 people worldwide. It is generally characterized by the appearance of spontaneous, recurrent and unpredictable seizures. Approximately one-third of epileptic patients cannot control their seizures with current medications, while the remaining two-thirds of patients often experience negative cognitive side effects, highlighting the need to better understand epilepsy mechanisms. A common theme in multiple seizure models is that cellular swelling is necessary for seizure initiation and recurrence. In experiments described

Astrocytes in Patho Physiology of the Nervous System

Astrocytes in  Patho Physiology of the Nervous System
  • Author : Vladimir Parpura,Philip G. Haydon
  • Publisher : Springer Science & Business Media
  • Release : 11 December 2008
GET THIS BOOK Astrocytes in Patho Physiology of the Nervous System

Astrocytes were the original neuroglia that Ramón y Cajal visualized in 1913 using a gold sublimate stain. This stain targeted intermediate filaments that we now know consist mainly of glial fibrillary acidic protein, a protein used today as an astrocytic marker. Cajal described the morphological diversity of these cells with some ast- cytes surrounding neurons, while the others are intimately associated with vasculature. We start the book by discussing the heterogeneity of astrocytes using contemporary tools and by calling into

Seizure Induced Gliogenesis in the Piriform Cortex microform

Seizure Induced Gliogenesis in the Piriform Cortex  microform
  • Author : Mani Vessal
  • Publisher : Library and Archives Canada = Bibliothèque et Archives Canada
  • Release : 18 September 2021
GET THIS BOOK Seizure Induced Gliogenesis in the Piriform Cortex microform

Complex partial epilepsy is a seizure disorder in which attacks frequently arise from foci located in the temporal lobes. The amygdala-kindling model is a widely used model of complex partial epilepsy with secondary generalization. The present study was designed to (1) quantitatively assess astrocytic changes in the rat piriform cortex in the amygdala-kindling model of epilepsy. (2) to assess the functional role of astrocytic proliferation in the kindling process. In the fully kindled subjects, once the experimental subjects reached five stage 5 seizures,

Epilepsy as a Dynamic Disease

Epilepsy as a Dynamic Disease
  • Author : John Milton,Peter Jung
  • Publisher : Springer Science & Business Media
  • Release : 17 April 2013
GET THIS BOOK Epilepsy as a Dynamic Disease

The first book to bring together experts in epilepsy, bio-engineering and dynamical systems theory, to discuss the possibility of treating epilepsy by controlling mechanisms that cause seizures. It includes a unique reference database with more than 1000 references, including hard-to-access references in the Russian literature.

Models of Seizures and Epilepsy

Models of Seizures and Epilepsy
  • Author : Asla Pitkänen,Paul Buckmaster, DVM, PhD,Aristea S Galanopoulou,Solomon L. Moshé
  • Publisher : Academic Press
  • Release : 14 June 2017
GET THIS BOOK Models of Seizures and Epilepsy

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of

Encyclopedia of Basic Epilepsy Research

Encyclopedia of Basic Epilepsy Research
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 27 May 2009
GET THIS BOOK Encyclopedia of Basic Epilepsy Research

As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent

Novel Viral and Astrocytic Contributors to Epilepsy

Novel Viral and Astrocytic Contributors to Epilepsy
  • Author : Julie Chen
  • Publisher : Unknown
  • Release : 18 September 2021
GET THIS BOOK Novel Viral and Astrocytic Contributors to Epilepsy

Epilepsy is a neurological seizure disorder affecting approximately 1% of the world's population. Seizure disorders are numerous, heterogeneous, and can develop from a multitude of physiological conditions including but not limited to interneuron dysfunction, ion channel mutations, irregular development and layering of the cerebral cortex, abnormalities in cell signaling pathways, brain tumors, traumatic brain injuries, and mitochondrial diseases. In many seizure disorders, gene mutations (primary) cause physiological abnormalities (secondary) that result in seizures. In some cases, the primary cause of epilepsy

Clinical and Genetic Aspects of Epilepsy

Clinical and Genetic Aspects of Epilepsy
  • Author : Zaid Afawi
  • Publisher : BoD – Books on Demand
  • Release : 15 September 2011
GET THIS BOOK Clinical and Genetic Aspects of Epilepsy

This book on Epilepsy was conceived and produced as a source of information on wide range of issues in epilepsy. We hope that it will help health care providers in daily practices and increase their understanding on diagnosis and treatment of epilepsies. The book was designed as an update for neuroscientists who are interested in epilepsy, primary care physicians and students in health care professions.

Inflammation and Epilepsy New Vistas

Inflammation and Epilepsy  New Vistas
  • Author : Damir Janigro,Astrid Nehlig,Nicola Marchi
  • Publisher : Springer Nature
  • Release : 18 May 2021
GET THIS BOOK Inflammation and Epilepsy New Vistas

This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute

Epilepsy and the Ketogenic Diet

Epilepsy and the Ketogenic Diet
  • Author : Carl E. Stafstrom,Jong M. Rho
  • Publisher : Springer Science & Business Media
  • Release : 29 July 2004
GET THIS BOOK Epilepsy and the Ketogenic Diet

The Nutrition and Health series of books has an overriding mission to provide health professionals with texts that are considered essential because each includes: (1) a synthe sis of the state of the science, (2) timely, in -depth reviews by the leading researchers in their respective fields, (3) extensive, up-to-date, fully annotated reference lists, (4) a detailed index, (5) relevant tables and figures, (6) identification of paradigm shifts and the consequences, (7) suggestions of areas for future research, and (8) balanced, data driven answers to patient /health professionals