Animal Models in Cancer Drug Discovery

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  • Author : Asfar Azmi
  • Publisher : Academic Press
  • Pages : 470 pages
  • ISBN : 0128147059
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>Animal Models in Cancer Drug Discovery

Download or Read online Animal Models in Cancer Drug Discovery full in PDF, ePub and kindle. this book written by Asfar Azmi and published by Academic Press which was released on 16 April 2019 with total page 470 pages. We cannot guarantee that Animal Models in Cancer Drug Discovery book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery
  • Author : Asfar Azmi,Ramzi M. Mohammad
  • Publisher : Academic Press
  • Release : 16 April 2019
GET THIS BOOK Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized

Molecular Cancer Therapeutics

Molecular Cancer Therapeutics
  • Author : George C. Prendergast
  • Publisher : John Wiley & Sons
  • Release : 02 April 2004
GET THIS BOOK Molecular Cancer Therapeutics

Molecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry

Animal Models for Human Cancer

Animal Models for Human Cancer
  • Author : Marianne I. Martic-Kehl,Pius August Schubiger
  • Publisher : John Wiley & Sons
  • Release : 18 May 2016
GET THIS BOOK Animal Models for Human Cancer

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural

Tumor Models in Cancer Research

Tumor Models in Cancer Research
  • Author : Beverly A. Teicher
  • Publisher : Humana Press
  • Release : 02 December 2010
GET THIS BOOK Tumor Models in Cancer Research

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some

In vivo Models for Drug Discovery

In vivo Models for Drug Discovery
  • Author : José Miguel Vela,Rafael Maldonado,Michel Hamon
  • Publisher : John Wiley & Sons
  • Release : 11 August 2014
GET THIS BOOK In vivo Models for Drug Discovery

This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a

COX 2 Blockade in Cancer Prevention and Therapy

COX 2 Blockade in Cancer Prevention and Therapy
  • Author : Randall E. Harris
  • Publisher : Humana Press
  • Release : 28 October 2010
GET THIS BOOK COX 2 Blockade in Cancer Prevention and Therapy

The revelation that aspirin and aspirin-like compounds have notableantineo plastic properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five areas. First, an historical overview documents the scientific discovery ofCOX-2 and the pharma ceutical development of nonsteroidal anti-inflammatory drugs (NSAIDs) designed for selective COX-2 inhibition. The process by

Molecular Diagnostics and Treatment of Pancreatic Cancer

Molecular Diagnostics and Treatment of Pancreatic Cancer
  • Author : Asfar Azmi
  • Publisher : Elsevier
  • Release : 14 April 2014
GET THIS BOOK Molecular Diagnostics and Treatment of Pancreatic Cancer

Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses

Tumor Suppressor Genes in Human Cancer

Tumor Suppressor Genes in Human Cancer
  • Author : David E. Fisher
  • Publisher : Humana Press
  • Release : 28 October 2010
GET THIS BOOK Tumor Suppressor Genes in Human Cancer

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their

Cytokines in the Genesis and Treatment of Cancer

Cytokines in the Genesis and Treatment of Cancer
  • Author : Michael A. Caligiuri,Michael T. Lotze
  • Publisher : Springer Science & Business Media
  • Release : 19 September 2007
GET THIS BOOK Cytokines in the Genesis and Treatment of Cancer

Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. The book brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer.

Molecular Diagnostics and Treatment of Pancreatic Cancer

Molecular Diagnostics and Treatment of Pancreatic Cancer
  • Author : Asfar Azmi
  • Publisher : Academic Press
  • Release : 17 April 2014
GET THIS BOOK Molecular Diagnostics and Treatment of Pancreatic Cancer

Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses

What Will We Do If We Don t Experiment on Animals

What Will We Do If We Don t Experiment on Animals
  • Author : Jean Swingle Greek,C. Ray Greek
  • Publisher : Trafford Publishing
  • Release : 06 December 2021
GET THIS BOOK What Will We Do If We Don t Experiment on Animals

Drs. Greek have written 2 books on why using animals as models for humans is not the best way to conduct medical research and drug testing. During their lectures and debates, the most commonly asked question was, "Well. What will we use if we don't use animals?" What Will We Do If We Don't Experiment On Animals? Medical Research for the Twenty-first Century is the answer to that question. Drs. Greek explain briefly why one species cannot predict drug response for

The Oncogenomics Handbook

The Oncogenomics Handbook
  • Author : William J. LaRochelle,Richard A. Shimkets
  • Publisher : Springer Science & Business Media
  • Release : 09 November 2007
GET THIS BOOK The Oncogenomics Handbook

An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from

Oral Bioavailability Assessment

Oral Bioavailability Assessment
  • Author : Ayman F. El-Kattan
  • Publisher : John Wiley & Sons
  • Release : 15 May 2017
GET THIS BOOK Oral Bioavailability Assessment

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to

Animal Models for Human Cancer Volume 69

Animal Models for Human Cancer  Volume 69
  • Author : Marianne I. Martic-Kehl,Pius August Schubiger,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release : 15 August 2016
GET THIS BOOK Animal Models for Human Cancer Volume 69

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural

Translational Animal Models in Drug Discovery and Development

Translational Animal Models in Drug Discovery and Development
  • Author : Xinkang Wang
  • Publisher : Bentham Science Publishers
  • Release : 03 October 2012
GET THIS BOOK Translational Animal Models in Drug Discovery and Development

Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between