Animal Models for the Study of Human Disease

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  • Author : Jerrold Tannenbaum
  • Publisher : Elsevier Inc. Chapters
  • Pages : 1108 pages
  • ISBN : 0128071915
  • Rating : /5 from reviews
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Download or Read online Animal Models for the Study of Human Disease full in PDF, ePub and kindle. this book written by Jerrold Tannenbaum and published by Elsevier Inc. Chapters which was released on 29 May 2013 with total page 1108 pages. We cannot guarantee that Animal Models for the Study of Human Disease book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. This chapter presents an overview of ethical principles that are essential for the proper conduct, and the continuing progress, of animal research aimed at understanding human disease. The chapter identifies fundamental principles of animal research ethics, and discusses ethical and empirical foundations of these principles. Guidelines are offered for applying these fundamental principles in the design and implementation of animal research projects. The chapter highlights several important ethical issues regarding which the biomedical research community has expressed lack of clarity or disagreement, and suggests considerations that are relevant for resolution of these issues. Recommendations are offered for participation by investigators in ethical discussion of their work, and of biomedical animal research generally. The general themes of the chapter are that investigators play the primary role in assuring the ethical conduct of biomedical animal research, and that a crucial foundation of ethical animal research is sound science.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Jerrold Tannenbaum
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOK Animal Models for the Study of Human Disease

This chapter presents an overview of ethical principles that are essential for the proper conduct, and the continuing progress, of animal research aimed at understanding human disease. The chapter identifies fundamental principles of animal research ethics, and discusses ethical and empirical foundations of these principles. Guidelines are offered for applying these fundamental principles in the design and implementation of animal research projects. The chapter highlights several important ethical issues regarding which the biomedical research community has expressed lack of clarity

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Kristine Coleman,James L. Weed,Steven J. Schapiro
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOK Animal Models for the Study of Human Disease

Environmental enrichment is an integral part of animal care practices. Enrichment generally refers to items we provide to the animals to support their behavioral needs. It provides a way to functionally simulate the natural environment of captive animals, in an effort to increase opportunities for the expression of species-specific behaviors and decrease the occurrence of abnormal behaviors. Further, enrichment can also be a tool in the study of basic science questions, such as how environmental factors may affect disease etiology

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Matthew W. Kemp,Gabrielle C. Musk,Masatoshi Saito
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOK Animal Models for the Study of Human Disease

In industrialized and developing countries, preterm birth (live delivery before 39 weeks of gestation) is both a leading cause of neonatal death and a major risk factor for respiratory, neurological, and cognitive disabilities in those infants who survive to adolescence. Intrauterine infection is considered a leading cause of preterm birth; data from clinical and experimental studies suggest that in utero infection accounts for upward of 40% of preterm deliveries. This chapter is written with two aims: the first is to provide the

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Sara I. Ruiz,Elizabeth E. Zumbrun,Aysegul Nalca
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOK Animal Models for the Study of Human Disease

As the threat of exposure to emerging and reemerging viruses within a naive population increases, it is vital that the basic mechanisms of pathogenesis and immune response be thoroughly investigated. By using animal models in this endeavor, the response to viruses can be studied in a more natural context to identify novel drug targets, and assess the efficacy and safety of new products. This is especially true in the advent of the Food and Drug Administration's animal rule. Although no

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Li Chen,Richard P. Shannon,You-Tang Shen
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOK Animal Models for the Study of Human Disease

With advances in molecular and genomic research offering novel insights into cardiovascular diseases, many transgenic animal models have been recently developed and characterized. Currently, more than 90 percent of all laboratory animal experiments are conducted in mice and rats. Although there are many scientific advantages to using small animal models, it has been recently recognized that many exciting therapeutic targets identified in small animals are not validated in clinical trials in patients. Thus, suitable large animal models, particularly under conscious state

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Bernhard Aigner,Barbara Kessler,Nikolai Klymiuk,Mayuko Kurome,Simone Renner,Annegret Wünsch,Eckhard Wolf
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOK Animal Models for the Study of Human Disease

Basic research of the pathobiology of diseases as well as of therapeutic strategies usually is carried out in rodents as animal models. Translational research that transfers novel results from basic research to clinical application often requires analyses in additional nonrodent models and/or large animal models that share specific pathophysiological characteristics with the human diseases in question. As prerequisites for the generation of appropriate disease models by genetic engineering, pigs exhibit suitable reproductive performance traits, pig genome analyses resulted in

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Soudabeh Imanikia,Stephen R. Stürzenbaum
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOK Animal Models for the Study of Human Disease

An imbalance between energy uptake and energy expenditure can lead to obesity. In addition to the modulation of fundamental pathways, obesity can increase the risk of coronary heart diseases, high blood pressure, stroke, type II diabetes and some cancers. Given that key elements of the energy pathways (both sugar and fat) are evolutionary conserved, invertebrate research is an attractive alternative that overcome the many legislative, financial and experimental hurdles typical of research with higher metazoan animals. The premier invertebrate models

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Atsushi Mizoguchi,Akira Andoh
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOK Animal Models for the Study of Human Disease

Inflammatory bowel disease (IBD) is a chronic, relapsing intestinal inflammatory condition with increasing incidence and prevalence around the world. Conventional and biological therapies have been successfully, or unsuccessfully, applied for the treatment of IBD and several new biological therapies are currently in clinical development. So far, more than 69 kinds of animal models have been established to study IBD, and they have provided significant contributions not only for understanding the mechanism of IBD but also for developing the rationale of new

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Victoria E. O’Collins,Geoffrey A. Donnan,Malcolm R. Macleod,David W. Howells
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOK Animal Models for the Study of Human Disease

A quantitative and qualitative comparison of contemporary neuroprotection and thrombolytic stroke trials and their preclinical animal counterparts has been undertaken, with meta-analysis (DerSimonian and Laird, 1986) used to evaluate imaging and histological outcomes. Results from 35 clinical trials including 5,532 patients were compared with data from 3,145 pre-clinical acute-stroke experiments in 45,476 animals. While clinical trials tended to be of higher methodological quality and have larger sample sizes than animal experiments (71 patients vs. 7 animals per group), both were similarly underpowered owing to the greater variability

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Lixin Kan
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOK Animal Models for the Study of Human Disease

Bone disorders have a major impact on general population and cover a broad spectrum of diseases. At one end of the spectrum are the common disorders that are featured with age related progressive degeneration, and at the other end are the rare but serious congenital abnormities. Deeper understanding of the underlying mechanisms is a key to ensure the timely diagnosis, cost-effective prevention and treatment of these disorders. Animal models that could mimic the human pathologic conditions are tremendous helpers to

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Joshua G. Hunter,John L. Daiss,Stephen L. Kates,Edward M. Schwarz
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOK Animal Models for the Study of Human Disease

Osteomyelitis, or an infection of the bone, remains a major orthopaedic problem without a solution. As these unmet needs stem from our limited knowledge of microbial pathogenesis of chronic osteomyelitis, and the host response required for protective immunity, animal models of bone infection are still being developed after more than a century of research. Moreover, since osteomyelitis research spans the fields of microbiology, immunology, bone biology, biomechanics, orthopaedics and pre-clinical testing of drugs, vaccines and implants, the animal models used

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Meghan E. McGee-Lawrence,Frank J. Secreto,Farhan A. Syed
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOK Animal Models for the Study of Human Disease

The skeleton is a multifunctional organ system that serves several vital roles in the body. Although bone has the ability to remodel itself to repair damage and respond to calcium demands, it is subject to the rigors of aging, hormonal changes, and environment. Understanding the mechanisms that cause bone loss is an important facet of human medicine. Animal models permit mechanistic study of processes that regulate development and maintenance of skeletal mass, enabling meticulous investigation of new orthopedic strategies or

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Mengqi Chen,Doris Kretzschmar,Giuseppe Verdile,Michael Lardelli
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOK Animal Models for the Study of Human Disease

Alzheimer’s disease (AD) is a major and increasing burden on families, communities, and national health budgets. Despite intensive and extended research, there is still widespread debate about its cause(s), and no effective treatments exist. Familial (inherited, mainly early onset) and sporadic (mainly late onset) forms of the disease exist, and it is uncertain to what extent they are related. Transgenic mouse models have dominated the investigation of this disease, but their validity can be questioned. Numerous alternative models

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : JoEllen Welsh
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOK Animal Models for the Study of Human Disease

Breast cancer is one of the most frequently diagnosed malignancies, and despite extensive molecular and cellular research, the mortality rate remains high. Preclinical testing of new strategies to prevent the emergence of invasive disease and to effectively treat existing disease is dependent on appropriate in vivo models. The challenges with modeling breast cancer in animals include species differences in mammary gland development and sensitivity to carcinogens as well as the molecular heterogeneity of human breast cancer. This chapter focuses on