From Structure to Clinical Development Allosteric Modulation of G Protein Coupled Receptors

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  • Author : Christopher J. Langmead
  • Publisher : Academic Press
  • Pages : 312 pages
  • ISBN : 0128201878
  • Rating : /5 from reviews
CLICK HERE TO GET THIS BOOK >>>From Structure to Clinical Development Allosteric Modulation of G Protein Coupled Receptors

Download or Read online From Structure to Clinical Development Allosteric Modulation of G Protein Coupled Receptors full in PDF, ePub and kindle. this book written by Christopher J. Langmead and published by Academic Press which was released on 01 June 2020 with total page 312 pages. We cannot guarantee that From Structure to Clinical Development Allosteric Modulation of G Protein Coupled Receptors book is available in the library, click Get Book button and read full online book in your kindle, tablet, IPAD, PC or mobile whenever and wherever You Like. From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo‐switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP‐1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure‐based discovery and development of mGlu5 NAMs, and much more.

From Structure to Clinical Development Allosteric Modulation of G Protein Coupled Receptors

From Structure to Clinical Development  Allosteric Modulation of G Protein Coupled Receptors
  • Author : Christopher J. Langmead
  • Publisher : Academic Press
  • Release : 01 June 2020
GET THIS BOOK From Structure to Clinical Development Allosteric Modulation of G Protein Coupled Receptors

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo‐switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP‐1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction,

Oligomerization and Allosteric Modulation in G Protein Coupled Receptors

Oligomerization and Allosteric Modulation in G Protein Coupled Receptors
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 02 December 2012
GET THIS BOOK Oligomerization and Allosteric Modulation in G Protein Coupled Receptors

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research. Contributions from leading authorities Informs and updates on all the latest developments

Allosteric Modulation of G Protein Coupled Receptors

Allosteric Modulation of G Protein Coupled Receptors
  • Author : Robert B Laprairie
  • Publisher : Academic Press
  • Release : 15 May 2022
GET THIS BOOK Allosteric Modulation of G Protein Coupled Receptors

Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) allosteric modulation and presents original research in the area, which collectively provides a comprehensive description of the key issues in GPCR allosteric modulation. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signalling at a site apart from the endogenous

Dimer dependent Allosteric Modulation Within GPCR Signalling Complexes Can Influence Signalling Diversity

Dimer dependent Allosteric Modulation Within GPCR Signalling Complexes Can Influence Signalling Diversity
  • Author : Katrin Altosaar
  • Publisher : Unknown
  • Release : 22 January 2022
GET THIS BOOK Dimer dependent Allosteric Modulation Within GPCR Signalling Complexes Can Influence Signalling Diversity

"G protein-coupled receptors (GPCRs) comprise the largest group of cell surface receptors, translating environmental signals into cellular responses via cognate G protein partners. Contrary to our initial understanding, most GPCRs do not function in living cells as monomers, but most likely dimers, or even larger arrays of receptors. Standard drug design approaches rely on the notion that drugs binding the two receptors in a given dimer likely function independently of one another. However, this view has been challenged by recent

Biased Signaling and Allosteric Modulation of the Angiotensin II Type 1 Receptor

Biased Signaling and Allosteric Modulation of the Angiotensin II Type 1 Receptor
  • Author : Stephanie Clement
  • Publisher : Unknown
  • Release : 22 January 2022
GET THIS BOOK Biased Signaling and Allosteric Modulation of the Angiotensin II Type 1 Receptor

"G protein coupled receptors (GPCR) represent over 30% of drug targets and are involved in nearly all physiological and cellular responses. The angiotensin II (AngII) type I receptor (AT1R) is an important member of this receptor family. Its main endogenous ligand is the hormone angiotensin II (AngII), which regulates blood volume and vascular resistance, through the renin-angiotensin system (RAS). This hormone is involved in hypertension and other cardiovascular diseases. A way to improve today's therapeutic approach is to aim for

From Structure to Clinical Development Allosteric Modulation of G Protein Coupled Receptors

From Structure to Clinical Development  Allosteric Modulation of G Protein Coupled Receptors
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 13 May 2020
GET THIS BOOK From Structure to Clinical Development Allosteric Modulation of G Protein Coupled Receptors

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo-switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP-1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs

Pharmacology of G Protein Coupled Receptors

Pharmacology of G Protein Coupled Receptors
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 08 September 2011
GET THIS BOOK Pharmacology of G Protein Coupled Receptors

G protein coupled receptors remain the most important class of therapeutic targets in medicine. In the last 5 years, tremendous advances have been made in our understanding of the structure and mechanism of this critical family of drug targets. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors. It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological

GPCRs

GPCRs
  • Author : Beata Jastrzebska,Paul S.-H. Park
  • Publisher : Academic Press
  • Release : 11 September 2019
GET THIS BOOK GPCRs

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible

Allosteric Modulation of the Human Cannabinoid 1 Receptor

Allosteric Modulation of the Human Cannabinoid 1 Receptor
  • Author : Derek M. Shore
  • Publisher : Unknown
  • Release : 22 January 2022
GET THIS BOOK Allosteric Modulation of the Human Cannabinoid 1 Receptor

"The human cannabinoid-1 (CB1) receptor is a Class A, rhodopsin-like G protein-coupled receptor (GPCR). CB1 is found primarily in the central nervous system (CNS) where it participates in the regulation of neuronal activity; consequently, it is not surprising that this receptor has been implicated in numerous pathologies, including Alzheimer's disease, cancer, obesity, and pain. Unfortunately, many attempts at therapeutically targeting CB1 have failed, due to unacceptable CNS-related side effects; specifically, attempts to target CB1's orthosteric binding site (i.e.

Allosteric Receptor Modulation in Drug Targeting

Allosteric Receptor Modulation in Drug Targeting
  • Author : Norman G. Bowery
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOK Allosteric Receptor Modulation in Drug Targeting

Offering a wide array of illustrations and tables in every chapter, this book extensively covers the principles of allosterism in reference to drug action and progresses to a detailed examination of individual ionotropic and G-protein coupled receptor systems-helping those new to the subject understand the importance of allosterism and providing th